Department of Pathology, Tongji University School of Medicine, Shanghai, China.
Brain Pathol. 2011 Sep;21(5):607-10. doi: 10.1111/j.1750-3639.2011.00521.x.
Extramedullary hematopoiesis (EMH), defined as the presence of hematopoiesis outside bone marrow and peripheral blood, occurs asa compensatory phenomenon in several hematologic disorders and bone marrow dysfunction. EMH predominantly affects reticuloendothelial system including the spleen, liver and lymph nodes. Here,we report a rare case of multiple intracranial meningeal EMH. A37-year-old woman was anemic with gradually worsening vision for 8 months. Multiple extra-axial masses were found on imaging and the patient underwent the biopsy for the left frontotemporal lesion.Final diagnosis was multiple intracranial meningeal EMH. Treatment of fractionated external beam radiotherapy resulted in marked symptomatic improvement. This case indicates that although the diagnosis of meningeal EMH is difficult, there is a need to consider EMHin the differential diagnosis of anemic patients with tumor-like mass lesions in extramedullary sites.
骨髓外造血（EMH）是指骨髓外和外周血中存在造血，是几种血液系统疾病和骨髓功能障碍的代偿现象。EMH 主要影响网状内皮系统，包括脾脏、肝脏和淋巴结。在这里，我们报告了一例罕见的颅内脑膜多处 EMH 病例。一名 37 岁女性因贫血伴进行性视力恶化 8 个月就诊。影像学检查发现多处颅外轴外肿块，患者接受了左额颞病变的活检。最终诊断为多处颅内脑膜 EMH。分次外照射治疗后症状明显改善。本例表明，尽管脑膜 EMH 的诊断困难，但对于骨髓外部位有肿瘤样肿块病变的贫血患者，需要考虑 EMH 的鉴别诊断。
