调节性细胞因子决定了假性剥脱综合征产生过程中炎症的结局。

Regulatory cytokines prescribe the outcome of the inflammation in the process of pseudoexfoliation production.

机构信息

Department of Ophthalmology, Faculty of Medical Sciences, Clinical Center Kragujevac, University of Kragujevac, Serbia.

Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, Serbia.

出版信息

J Chin Med Assoc. 2019 Dec;82(12):935-940. doi: 10.1097/JCMA.0000000000000214.

DOI:10.1097/JCMA.0000000000000214

PMID:31800535

Abstract

BACKGROUND

The purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX).

METHODS

Our study included 140 patients referred to cataract surgery with early and late stage of pseudoexfoliation syndrome (XFS) or pseudoexfoliation glaucoma (XFG). Humor and serum levels of cytokines: transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), IL-8 and interferon-inducible T cell alpha chemoattractant (ITAC) were measured in a sample using high sensitivity enzyme-linked immunoabsorbent assay (ELISA) kit.

RESULTS

Our results indicate that profibrotic action induced by increasing TGF-β and PDGF locally activates fibrous tissue production in the early XFS with a prolonged effect of PDGF (late XFS) and finally (XFG stage) it is dominantly controlled by EGF and IGF. ITAC overrides angiogenetic effects of IL-8 in XFG.

CONCLUSION

Based on our findings, local chronic inflammation in the eye is accompanied by the secretion of different profibrotic cytokines (TGF-β, PDGF, EGF, IGF, IL-8) without angiogenesis due to effects of ITAC.

摘要

背景

本研究旨在揭示不同调节性细胞因子在假性剥脱（PEX）过程中的作用。

方法

我们的研究包括 140 名因白内障手术而就诊的患者，他们患有早期和晚期假性剥脱综合征（XFS）或假性剥脱性青光眼（XFG）。使用高灵敏度酶联免疫吸附试验（ELISA）试剂盒在样本中测量细胞因子转化生长因子-β（TGF-β）、血小板衍生生长因子（PDGF）、表皮生长因子（EGF）、胰岛素样生长因子（IGF）、IL-8 和干扰素诱导的 T 细胞α趋化因子（ITAC）在房水和血清中的水平。