糖蛋白-1作为接受表皮生长因子受体酪氨酸激酶抑制剂治疗的晚期肺腺癌脑转移患者的生物标志物
Glycodelin As A Biomarker Of Advanced Lung Adenocarcinoma Brain Metastases In Patients Treated With EGFR Tyrosine Kinase Inhibitors.
作者信息
Ni Zexu, Zhang Lingling, Zheng Jinhua, Su Xiaojie, Zhang Shucai
机构信息
Department of Pathology, Dongguan Tungwah Hospital, Dongguan 523110, People's Republic of China.
Department of Oncology, Beijing Chest Hospital, Capital Medical University; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, People's Republic of China.
出版信息
Cancer Manag Res. 2019 Nov 6;11:9421-9425. doi: 10.2147/CMAR.S216971. eCollection 2019.
OBJECTIVE
Brain metastasis (BM) is a serious complication of advanced lung adenocarcinoma and is a prominent factor leading to lung cancer mortality. In this study, the expression of the glycodelin protein was analyzed in EGFR-mutant tyrosine kinase inhibitor-sensitive advanced lung adenocarcinoma.
METHODS
This study features a retrospective analysis of 74 advanced lung adenocarcinoma patients treated at our hospital from January 2010 to December 2017. The expressions of glycodelin were assessed by standard immunohistochemistry and correlated with clinicopathological factors and overall survival (OS) outcomes.
RESULTS
Patients with advanced lung adenocarcinoma with glycodelin overexpression were prone to BM (P < 0.05), and exhibited significantly shortened OS (11.8 months vs 20.4 months, P < 0.05). Multivariate regression analysis showed that overexpression of glycodelin and brain metastases were independent factors affecting the prognosis of advanced lung adenocarcinoma (P < 0.05).
CONCLUSION
The overexpression of glycodelin is closely related to the presence of brain metastasis in lung adenocarcinoma, and can be used as an auxiliary diagnostic index for prognosis of advanced lung adenocarcinoma.
目的
脑转移（BM）是晚期肺腺癌的严重并发症，也是导致肺癌死亡的一个突出因素。在本研究中，对表皮生长因子受体（EGFR）突变型酪氨酸激酶抑制剂敏感的晚期肺腺癌中糖蛋白15（glycodelin）的表达进行分析。
方法
本研究对2010年1月至2017年12月在我院接受治疗的74例晚期肺腺癌患者进行回顾性分析。采用标准免疫组织化学方法评估glycodelin的表达，并与临床病理因素及总生存期（OS）结果进行相关性分析。
结果
glycodelin过表达的晚期肺腺癌患者易发生脑转移（P<0.05），且总生存期显著缩短（11.8个月对20.4个月，P<0.05）。多因素回归分析显示，glycodelin过表达和脑转移是影响晚期肺腺癌预后的独立因素（P<0.05）。
结论
glycodelin过表达与肺腺癌脑转移的发生密切相关，可作为晚期肺腺癌预后的辅助诊断指标。
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