印度东北部地区癌症中心儿童急性淋巴细胞白血病的临床流行病学特征及反应
Clinico-epidemiological features and response in childhood acute lymphoblastic leukemia at regional cancer center of Northeast India.
作者信息
Saikia Bhargab Jyoti, Roy Partha Sarathi, Kumar Gaurav, Mishra Rakesh Kumar, Sarma Anupam
机构信息
Department of Medical Oncology, Dr. B Borooah Cancer Institute, Guwahati, Assam, India.
Department of Pathology, Dr. B Borooah Cancer Institute, Guwahati, Assam, India.
出版信息
South Asian J Cancer. 2019 Oct-Dec;8(4):241-243. doi: 10.4103/sajc.sajc_249_19.
INTRODUCTION
Acute lymphoblastic leukemia (ALL) comprises 19.3% of all childhood cancers in Northeast India.
METHODS
We analyzed clinicoepidemiological features and early response to the treatment of all the cases of childhood ALL (age <15 years) diagnosed and treated at Dr. B Borooah Cancer Institute over 1 year.
RESULTS
Of 52 eligible cases, 69% were male (male:female ratio of 2.2:1) and the mean age was 7.1 years. Thirty-three children (63%) had baseline white blood cell count ≥20 × 10/L. Precursor B-cell was most the common subtype seen in 61% of children. Seven cases (14%) had high-risk (HR) cytogenetics, with (9,22) being the most common one. Male sex and HR cytogenetics were significantly associated with poor early responses.
CONCLUSION
ALL is a common childhood malignancy with high cure rates. However, poor socioeconomic status and the presence of higher proportions of disease-related factors lead to poor outcome in this part of the country.
引言
急性淋巴细胞白血病（ALL）占印度东北部所有儿童癌症的19.3%。
方法
我们分析了在博拉奥阿博士癌症研究所确诊并接受治疗的所有1年内确诊的儿童ALL（年龄<15岁）病例的临床流行病学特征和治疗早期反应。
结果
在52例符合条件的病例中，69%为男性（男女比例为2.2:1），平均年龄为7.1岁。33名儿童（63%）基线白细胞计数≥20×10/L。前体B细胞是最常见的亚型，见于61%的儿童。7例（14%）有高危（HR）细胞遗传学异常，其中（9,22）是最常见的。男性性别和HR细胞遗传学与早期反应差显著相关。
结论
ALL是一种常见的儿童恶性肿瘤，治愈率高。然而，社会经济地位低下以及疾病相关因素比例较高导致该国这一地区的预后较差。
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