用于自体器官移植的人兽嵌合体：技术进展与未来展望。
Human-animal chimeras for autologous organ transplantation: technological advances and future perspectives.
作者信息
Lu Yingfei, Zhou Yu, Ju Rong, Chen Jianquan
机构信息
Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China.
Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China.
出版信息
Ann Transl Med. 2019 Oct;7(20):576. doi: 10.21037/atm.2019.10.13.
Organ transplantation is the most promising curation for end-stage organ disease. However, the donor organ shortage has become a global problem that has limited the development of organ transplantation. Human-animal chimeras provide the ability to produce human organs in other species using autologous stem cells [e.g., induced pluripotent stem cells (iPSCs) or adult stem cells], which would be patient-specific and immune-matched for transplantation. Due to the potential application prospect of interspecies chimeras in basic and translational research, this technology has attracted much interest. This review focuses primarily on technological advances, including options of donor stem cell types and gene editing in donor cells and host animals, in addition to perspectives on human-animal chimeras in clinical and basic research.
器官移植是治疗终末期器官疾病最有前景的疗法。然而，供体器官短缺已成为一个全球性问题，限制了器官移植的发展。人兽嵌合体能够利用自体干细胞（如诱导多能干细胞或成体干细胞）在其他物种中产生人类器官，这些器官将是患者特异性的，并且在移植时具有免疫匹配性。由于种间嵌合体在基础研究和转化研究中的潜在应用前景，这项技术引起了广泛关注。本综述主要关注技术进展，包括供体干细胞类型的选择以及供体细胞和宿主动物中的基因编辑，此外还探讨了人兽嵌合体在临床和基础研究中的前景。
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