Poles Marietta Zita, Juhász László, Boros Mihály
Institute of Surgical Research, University of Szeged, Pulz u. 1., Szeged, H-6724, Hungary.
Intensive Care Med Exp. 2019 Dec 5;7(1):68. doi: 10.1186/s40635-019-0278-6.
Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally considered to be biologically inactive. However, recent studies have provided evidence for methane bioactivity in various in vivo settings. The administration of methane either in gas form or solutions has been shown to have anti-inflammatory and neuroprotective effects in an array of experimental conditions, such as ischemia/reperfusion, endotoxemia and sepsis. It has also been demonstrated that exogenous methane influences the key regulatory mechanisms and cellular signalling pathways involved in oxidative and nitrosative stress responses. This review offers an insight into the latest findings on the multi-faceted organ protective activity of exogenous methane treatments with special emphasis on its versatile effects demonstrated in sepsis models.
哺乳动物体内的甲烷生成被视为厌氧胃肠道菌群进行碳水化合物发酵的一个指标。一旦由微生物产生或通过非细菌过程释放，甲烷通常被认为是没有生物活性的。然而，最近的研究已经为甲烷在各种体内环境中的生物活性提供了证据。在一系列实验条件下，如缺血/再灌注、内毒素血症和脓毒症中，以气体形式或溶液形式给予甲烷已显示出具有抗炎和神经保护作用。还已证明外源性甲烷会影响参与氧化应激和亚硝化应激反应的关键调节机制和细胞信号通路。本综述深入探讨了外源性甲烷治疗多方面器官保护活性的最新研究结果，特别强调了其在脓毒症模型中所展现的多种作用。
