Lambova Sevdalina Nikolova, Müller-Ladner Ulf
Department of Propaedeutics of Internal Diseases, Faculty of Medicine, Medical University, Plovdiv, Bulgaria.
Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Giessen, Germany.
Int J Rheum Dis. 2020 Feb;23(2):207-215. doi: 10.1111/1756-185X.13760. Epub 2019 Dec 5.
Despite the great interest in capillaroscopy in systemic sclerosis (SSc), research on the possible combinations of different microvascular phenomena at different fingers in SSc patients have not been performed until now.
To assess the diversity of capillaroscopic findings in SSc.
The study includes analysis of the capillaroscopic findings in 40 SSc patients who were divided into the following categories: "scleroderma", type pattern - "early", "active", "late" phase, normal and/or nonspecific findings. The data were analyzed using descriptive statistics and t test.
In 77% of the patients, inhomogeneity of the capillaroscopic findings of the fingers was detected. The most frequent combinations of capillaroscopic patterns were "early + active" (n = 7), "active + late" phase (n = 7), "active" phase + normal and/or nonspecific findings (n = 6), "early + active" phase + normal and/or nonspecific findings (n = 4). Concomitant presence of normal and/or nonspecific findings and "late" phase was detected in only 3 cases.
Inhomogeneity of the capillaroscopic findings in SSc is a frequent phenomenon. The results indicate that combinations of "scleroderma" type capillaroscopic findings from different phases could be observed as well as concomitant appearance of pathological and normal/or nonspecific findings of different digits. This phenomenon could be a result of the complex action of different factors eg, disease duration, severity of Raynaud's phenomenon, presence of digital ulcers, local action of different angiogenic and angiostatic factors, gradual transition from one phase to another due to the extensive capillary area, therapeutic interventions.
尽管系统性硬化症（SSc）的毛细血管镜检查备受关注，但迄今为止尚未对SSc患者不同手指处不同微血管现象的可能组合进行研究。
评估SSc患者毛细血管镜检查结果的多样性。
该研究包括对40例SSc患者的毛细血管镜检查结果进行分析，这些患者被分为以下几类：“硬皮病”型模式——“早期”“活动期”“晚期”阶段、正常和/或非特异性表现。使用描述性统计和t检验对数据进行分析。
77%的患者检测到手指毛细血管镜检查结果不均匀。毛细血管镜模式最常见的组合为“早期+活动期”（n = 7）、“活动期+晚期”阶段（n = 7）、“活动期”阶段+正常和/或非特异性表现（n = 6）、“早期+活动期”阶段+正常和/或非特异性表现（n = 4）。仅在3例患者中检测到正常和/或非特异性表现与“晚期”阶段同时存在。
SSc患者毛细血管镜检查结果不均匀是一种常见现象。结果表明，可观察到不同阶段“硬皮病”型毛细血管镜检查结果的组合，以及不同手指病理表现与正常和/或非特异性表现的同时出现。这种现象可能是不同因素复杂作用的结果，例如疾病持续时间、雷诺现象的严重程度、指端溃疡的存在、不同血管生成和血管抑制因子的局部作用、由于广泛的毛细血管区域导致从一个阶段逐渐过渡到另一个阶段、治疗干预。
