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引入温度控制的相转变弹性蛋白样多肽到瞬态电子学中:实现具有局部瞬态的主动生物触发电子学。

Introducing Temperature-Controlled Phase Transition Elastin-like Polypeptides to Transient Electronics: Realization of Proactive Biotriggered Electronics with Local Transience.

机构信息

Department of Biomedical Engineering, School of Medicine , Tsinghua University , Beijing 100084 , China.

出版信息

ACS Appl Mater Interfaces. 2019 Dec 18;11(50):46490-46496. doi: 10.1021/acsami.9b14798. Epub 2019 Dec 6.

Abstract

Transient electronics have dramatically changed inner-body therapy in health care. They stand out because of their harmless dissolution in the human body with no lingering electronic trash. However, high-precision biomedical implants require programmable and serial remedy operations, and controlling the whole-device destruction is not proactive and precise. Thus, a novel biotriggered and temperature-controlled transient electronics fabrication method using elastin-like polypeptides (ELPs) as triggers is proposed. Biocompatible ELPs simply mixed with trace silver nanowire (AgNW) can serve as the "switch" for the electronics to respond to local temperature changes in deionized water, exhibiting an agile response time. A ratio gradient experiment of the ELPs and AgNW shows that more programmable and precise transience properties (initial resistance, ready time, response time, and stable resistance) can be achieved by using a designated proportion. Further, we validated that the 3D-printing-based ELP-triggering transient electronics fabrication method is very simple yet effective for preparing transient wireless charging LEDs. Transient devices comprising ELPs-AgNW and PLGA-Ag respond within 160 s below 10 °C and degrade within a certain period.

摘要

瞬态电子技术在医疗保健领域中极大地改变了体内治疗方式。它们的无害溶解特性在人体内脱颖而出,不会留下任何电子垃圾。然而,高精度生物医学植入物需要可编程和串行修复操作,而控制整个设备的破坏并不具有主动性和精确性。因此,提出了一种使用弹性蛋白样多肽(ELP)作为触发物的新型生物触发和温度控制瞬态电子制造方法。简单地将生物相容性的 ELP 与微量的银纳米线(AgNW)混合,就可以作为电子设备对去离子水中局部温度变化做出响应的“开关”,表现出敏捷的响应时间。ELP 和 AgNW 的比例梯度实验表明,通过指定比例可以实现更具可编程性和精确性的瞬态特性(初始电阻、准备时间、响应时间和稳定电阻)。此外,我们验证了基于 3D 打印的 ELP 触发瞬态电子制造方法对于制备瞬态无线充电 LED 非常简单且有效。包含 ELP-AgNW 和 PLGA-Ag 的瞬态器件在 10°C 以下 160 秒内响应,并在一定时间内降解。

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