Griffin T B, Stein A A, Coulston F
White Sands Research Center, Alamogordo, New Mexico 88310.
Ecotoxicol Environ Saf. 1988 Aug;16(1):11-24. doi: 10.1016/0147-6513(88)90012-7.
Male and female Long-Evans rats were exposed in inhalation chambers to vapors of nitroethane at concentrations of 100 or 200 ppm, 7 hr per day, 5 days per week for 2 years. During the study, general observations were made daily and body weights were obtained weekly for the first 6 months of the study and biweekly thereafter. Any rats that were found dead or sacrificed moribund during the 2-year exposure phase of the study were given a thorough gross examination and tissues were retained for microscopic examination. After 2 years of inhalation of nitroethane, all surviving rats were sacrificed and subjected to the same thorough gross examination. Blood samples were obtained from representative groups of animals for hematology and serum chemistry studies. All rats were examined histopathologically. Exposure of the rats to nitroethane had no pharmacologic effects nor were there any effects on mortality of rats of either sex at either level of exposure. Throughout most of the investigation, body weights of both sexes of both exposed groups were slightly less than those of respective controls, but lack of a well-defined dose-response relationship suggested the involvement of factors other than just exposure to nitroethane. There were no effects of exposure to nitroethane on hematology nor were there any biologically significant effects of exposure to nitroethane on clinical chemistry or on organ weights. No significant nonneoplastic or neoplastic pathology was found as a consequence of exposure of the rats to nitroethane.
将雄性和雌性Long-Evans大鼠置于吸入舱中，暴露于浓度为100或200 ppm的硝基乙烷蒸气中，每天7小时，每周5天，持续2年。在研究期间，每天进行一般观察，在研究的前6个月每周记录体重，之后每两周记录一次。在为期2年的暴露阶段，任何被发现死亡或濒死而处死的大鼠都进行了全面的大体检查，并保留组织用于显微镜检查。吸入硝基乙烷2年后，所有存活的大鼠被处死并进行同样全面的大体检查。从代表性动物组采集血样进行血液学和血清化学研究。所有大鼠都进行了组织病理学检查。大鼠暴露于硝基乙烷中没有药理学效应，在任何一个暴露水平下，对任何性别的大鼠死亡率也没有影响。在整个调查的大部分时间里，两个暴露组的雌雄大鼠体重均略低于各自的对照组，但缺乏明确的剂量反应关系表明，除了暴露于硝基乙烷外，还有其他因素的参与。暴露于硝基乙烷对血液学没有影响，对临床化学或器官重量也没有任何生物学上的显著影响。大鼠暴露于硝基乙烷后，未发现明显的非肿瘤性或肿瘤性病变。
