Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Clinical Laboratory of Henan Province, Zhengzhou, China.
Department of Clinical Laboratory, The Sixth People's Hospital of Zhengzhou City, Zhengzhou, China.
Diagn Microbiol Infect Dis. 2020 Feb;96(2):114956. doi: 10.1016/j.diagmicrobio.2019.114956. Epub 2019 Nov 26.
Two linezolid-resistant and teicoplanin-intermediate Staphylococcus epidermidis strains were isolated from blood cultures in China. The 2 S. epidermidis strains were methicillin-resistant and showed multidrug-resistance patterns; in addition, population analysis profiling/area under the curve (PAP/AUC) result showed heterogeneous resistant to vancomycin. Comparing to teicoplanin susceptible strains, the 2 isolates showed reduced autolytic activity. Pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) indicated that the 2 S. epidermidis isolates belonged to the same clone. Furthermore, the cfr gene, a G2576T mutation, and a novel C2146T mutation were detected in the 2 isolates. This was the first report of S. epidermidis simultaneously nonsusceptible to linezolid and teicoplanin in China.
两株耐利奈唑烷和替考拉宁中介的表皮葡萄球菌从中国的血培养中分离出来。这两株表皮葡萄球菌耐甲氧西林，表现出多种药物耐药模式；此外，种群分析谱/曲线下面积（PAP/AUC）结果显示对万古霉素的异质性耐药。与替考拉宁敏感株相比，这两株分离株的自溶活性降低。脉冲场凝胶电泳（PFGE）和多位点序列分型（MLST）表明，这两株表皮葡萄球菌分离株属于同一克隆。此外，在这两株分离株中检测到 cfr 基因、G2576T 突变和新型 C2146T 突变。这是中国首次报道同时对利奈唑烷和替考拉宁均不敏感的表皮葡萄球菌。
