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胃旁路或袖状胃切除术后 4 年以上的维生素 D 状态。

Vitamin D Status After Gastric Bypass or Sleeve Gastrectomy over 4 Years of Follow-up.

机构信息

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation and University Teaching Trust, Salford, UK.

出版信息

Obes Surg. 2020 Apr;30(4):1473-1481. doi: 10.1007/s11695-019-04318-0.

Abstract

BACKGROUND

Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.

AIMS

To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.

PARTICIPANTS AND SETTING

Patients undergoing bariatric surgery in a university teaching hospital in North West England.

METHODS

We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent bariatric surgery. Patients were routinely recommended daily combined calcium and vitamin D supplementation post-surgery.

RESULTS

We studied 460 patients who had completed at least 12 months post-operatively; mean (standard deviation) age was 48.0 (10.5) years, weight 144.7 (27.3) kg and body mass index 50.0 (7.6) kg/m; 292 (63.5%) underwent gastric bypass and 168 (36.5%) sleeve gastrectomy. Vitamin D level was 33.1 (23.9) nmol/L at baseline, rising to 57.1 (23.1) nmol/L at 12 months post-surgery. Whereas 43.2% had vitamin D deficiency and 34.7% insufficiency preoperatively, 8.9% and 26.7% had deficiency and insufficiency, respectively, at 12 months with similar trends up to 4 years of follow-up. There were no significant differences between procedures or sexes in vitamin D levels or sufficiency rates.

CONCLUSION

Vitamin D deficiency and insufficiency were prevalent pre-surgery and reduced significantly with routine supplementation post-surgery.

摘要

背景

严重肥胖症的减重手术会导致微量营养素/维生素缺乏。

目的

研究减重手术后患者维生素 D 缺乏的基线和术后患病率。

参与者和设置

在英格兰西北部一所大学教学医院接受减重手术的患者。

方法

我们对接受减重手术的患者进行了维生素 D 及相关参数的纵向数据的观察性队列分析。患者术后常规推荐每日联合补充钙和维生素 D。

结果

我们研究了 460 名至少完成 12 个月术后随访的患者;平均(标准差)年龄为 48.0(10.5)岁,体重 144.7(27.3)kg,体重指数 50.0(7.6)kg/m;292 名(63.5%)接受胃旁路手术,168 名(36.5%)接受袖状胃切除术。基线时维生素 D 水平为 33.1(23.9)nmol/L,术后 12 个月时升高至 57.1(23.1)nmol/L。术前 43.2%有维生素 D 缺乏,34.7%有不足,术后 12 个月分别有 8.9%和 26.7%有缺乏和不足,在 4 年的随访中也有类似的趋势。手术或性别在维生素 D 水平或充足率方面没有显著差异。

结论

术前维生素 D 缺乏和不足很常见,术后常规补充可显著减少。

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