Faqihi Essa J, Alregaiey Khalid, Altuwayjiri Mohammed A, Alamri Mohammad N, Alshehri Bader A, Iqbal Muhammad
Physiology, King Saud University, Riyadh, SAU.
Cureus. 2022 Dec 20;14(12):e32733. doi: 10.7759/cureus.32733. eCollection 2022 Dec.
Objectives Obesity is viewed as a risk factor for several life-threatening diseases. Bariatric surgeries are regarded as a safe and effective way of treating morbid obesity and are associated with alterations in molecules such as Vitamin D and retinol-binding protein 4 (RBP4). The aim of this study was to examine an association between Vitamin D and RBP4 in healthy obese individuals undergoing gastric sleeve surgery. Methods In this observational retrospective cohort study, we used clinical and biochemical profiles of morbidly obese healthy male subjects (BMI > 38.3) who underwent laparoscopic sleeve gastrectomy. RBP4 levels were evaluated by ELISA before and 6-12 months after surgery. Data were analysed using SPSS 23 statistical software. Results RBP4/Vitamin D ratio was reduced significantly after surgery (p < 0.001), however, there was no correlation between Vitamin D and RBP4 (p = 0.353). BMI was reduced significantly after surgery (p < 0.001) but was not correlated with RBP4 or Vitamin D levels before and after surgery (p > 0.05). A significant increase in the levels of calcium post-surgery was observed (p< 0.001). Conclusions In conclusion, plasma levels of Vitamin D were not correlated with RBP4 before or after laparoscopic gastric sleeve surgery.
目的 肥胖被视为多种危及生命疾病的危险因素。减肥手术被认为是治疗病态肥胖的一种安全有效的方法，且与维生素D和视黄醇结合蛋白4（RBP4）等分子的变化有关。本研究的目的是探讨接受胃袖状切除术的健康肥胖个体中维生素D与RBP4之间的关联。方法 在这项观察性回顾性队列研究中，我们使用了接受腹腔镜袖状胃切除术的病态肥胖健康男性受试者（BMI > 38.3）的临床和生化资料。术前及术后6 - 12个月通过酶联免疫吸附测定法评估RBP4水平。使用SPSS 23统计软件进行数据分析。结果 术后RBP4/维生素D比值显著降低（p < 0.001），然而，维生素D与RBP4之间无相关性（p = 0.353）。术后BMI显著降低（p < 0.001），但与术前及术后RBP4或维生素D水平均无相关性（p > 0.05）。观察到术后钙水平显著升高（p< 0.001）。结论 总之，腹腔镜胃袖状切除术前或术后血浆维生素D水平与RBP4均无相关性。
