Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Cell Mol Gastroenterol Hepatol. 2018 Aug 23;6(4):451-462. doi: 10.1016/j.jcmgh.2018.07.004. eCollection 2018.
Micronutrients include electrolytes, minerals, vitamins, and carotenoids, and are required in microgram or milligram quantities for cellular metabolism. The liver plays an important role in micronutrient metabolism and this metabolism often is altered in chronic liver diseases. Here, we review how the liver contributes to micronutrient metabolism; how impaired micronutrient metabolism may be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a systemic disorder of energy, glucose, and lipid homeostasis; and how insights gained from micronutrient biology have informed NAFLD therapeutics. Finally, we highlight some of the challenges and opportunities that remain with investigating the contribution of micronutrients to NAFLD pathology and suggest strategies to incorporate our understanding into the care of NAFLD patients.
微量营养素包括电解质、矿物质、维生素和类胡萝卜素，其细胞代谢所需的量以微克或毫克计。肝脏在微量营养素代谢中发挥着重要作用，这种代谢在慢性肝病中常常发生改变。在这里，我们回顾了肝脏如何促进微量营养素代谢；受损的微量营养素代谢如何参与非酒精性脂肪性肝病（NAFLD）的发病机制，这是一种能量、葡萄糖和脂质稳态的系统性紊乱；以及从微量营养素生物学中获得的哪些见解为 NAFLD 治疗提供了信息。最后，我们强调了在研究微量营养素对 NAFLD 病理学的贡献方面仍然存在的一些挑战和机遇，并提出了将我们的认识纳入 NAFLD 患者治疗的策略。
