Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California.
Keck School of Medicine, University of Southern California, Los Angeles, California.
Pediatr Dev Pathol. 2020 Aug;23(4):312-316. doi: 10.1177/1093526619892352. Epub 2019 Dec 10.
Cartilaginous metaplasia involving the atrioventricular (AV) node is an uncommon entity that may cause sudden cardiac death secondary to dysrhythmias. We report 2 autopsy cases of full-term male newborns: 1 stillborn and 1 live-born, with antemortem bradycardia who died in the peripartum period. An examination of the cardiac conduction system in both cases demonstrated extensive cartilaginous metaplasia of the central fibrous body and involvement of the AV node and bundle of His. The cases highlight the recognition of cardiac conduction system anomalies as a cause of sudden perinatal death. In cases of perinatal death with preceding arrhythmia, postmortem sections of the cardiac conduction system are recommended to examine for cardiac conduction system anomaly.
涉及房室（AV）结的软骨化生是一种不常见的现象，可能会导致心律失常引起的心脏性猝死。我们报告了 2 例足月男性新生儿尸检病例：1 例为死产，1 例为活产，生前均有心动过缓，在围产期死亡。对这两例病例的心脏传导系统检查显示，中央纤维体有广泛的软骨化生，并累及 AV 结和希氏束。这些病例强调了将心脏传导系统异常识别为围产期猝死的原因。对于有先前心律失常的围产期死亡病例，建议进行心脏传导系统的死后切片检查，以检查心脏传导系统异常。
