From the Department of Pathology and Laboratory Medicine, Corewell Health, Grand Rapids, MI.
Am J Forensic Med Pathol. 2024 Mar 1;45(1):3-9. doi: 10.1097/PAF.0000000000000895. Epub 2023 Nov 17.
When a young previously healthy person dies suddenly, occasionally, the scene is noncontributory and the autopsy and drug screen are negative. In such cases, additional studies, including genetic assessment and cardiac conduction system examination, should be performed. We performed a literature search and reviewed our own material to identify possible or definite conduction system anomalies that may cause death. We identified intrinsic conduction system disease including cystic tumor of the atrioventricular node, atrioventricular node (cystic tumor of the AV node), and fibromuscular dysplasia of the atrioventricular node artery to be likely causes of death. Extrinsic causes, in which a generalized disease affects the conduction system, include tumors, autoimmune disease, infiltrative disorders, and others, are a second category of diseases that can affect the conduction system and cause atrioventricular block and sudden death.
当一个年轻且原本健康的人突然死亡时，偶尔情况下，现场并无明显贡献，尸检和药物筛查也呈阴性。在这种情况下，应进行其他研究，包括基因评估和心脏传导系统检查。我们进行了文献检索并回顾了自己的资料，以确定可能或确定的传导系统异常，这些异常可能导致死亡。我们确定了内在的传导系统疾病，包括房室结囊性肿瘤、房室结（房室结囊性肿瘤）和房室结动脉纤维肌性发育不良，这些疾病可能是导致死亡的原因。外在原因是全身性疾病影响传导系统，包括肿瘤、自身免疫性疾病、浸润性疾病等，这些疾病是第二类可能影响传导系统并导致房室传导阻滞和猝死的疾病。
