Geriatric Care Research Center, Department of Geriatric Nursing, School of Nursing and Midwifery, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
Eur J Med Chem. 2020 Feb 1;187:111951. doi: 10.1016/j.ejmech.2019.111951. Epub 2019 Dec 4.
Gynaecological disorders, such as cervical, ovarian, and endometrial cancers are the second most prevalent cancer types in women worldwide. Therapeutic approaches for gynaecological cancers involve chemotherapy, radiation, and surgery. However, lifespan is not improved, and novel medications are required. Among various phytochemicals, berberine, a well-known natural product, has been shown to be a promising cancer chemopreventive agent. Pharmacokinetics, safety, and efficacy of berberine have been investigated in the several experiments against numerous diseases. Here, we aimed to provide a literature review from available published investigations showing the anticancer effects of berberine and its various synthetic analogues against gynaecological disorders, including cervical, ovarian, and endometrial cancers. In conclusion, berberine has been found to efficiently inhibit viability, proliferation, and migration of cancer cells, mainly, via induction of apoptosis by both mitochondrial dependent and -independent pathways. Additionally, structural modification of berberine showed that berberine analogues can improve its antitumor effects against gynaecological cancers.
妇科疾病，如宫颈癌、卵巢癌和子宫内膜癌，是全球女性第二大常见癌症类型。妇科癌症的治疗方法包括化疗、放疗和手术。然而，患者的寿命并没有得到改善，因此需要新的药物。在各种植物化学物质中，小檗碱作为一种众所周知的天然产物，已被证明是一种很有前途的癌症化学预防剂。已经在多项针对多种疾病的实验中研究了小檗碱的药代动力学、安全性和疗效。在这里，我们旨在提供一份文献综述，从现有的已发表的研究中展示小檗碱及其各种合成类似物对妇科疾病（包括宫颈癌、卵巢癌和子宫内膜癌）的抗癌作用。总之，小檗碱已被发现能有效地抑制癌细胞的活力、增殖和迁移，主要通过线粒体依赖性和非依赖性途径诱导细胞凋亡。此外，小檗碱的结构修饰表明，小檗碱类似物可以提高其对妇科癌症的抗肿瘤作用。
