Student Research Committee, Islamic Azad University, Tehran Medical Branch, Tehran, Iran.
Student Research Committee, Islamic Azad University, Mashhad Medical Branch, Mashhad, Iran.
Curr Mol Med. 2024;24(10):1282-1290. doi: 10.2174/0115665240263630231009050436.
Urological cancers, encompassing prostate, kidney, and bladder cancers, pose significant global health challenges. Current treatment modalities, including chemotherapy, radiotherapy, and surgery, individually or in combination, have limitations in efficacy and are associated with notable morbidity and mortality.
This review explores alternative therapeutic avenues, emphasizing the exploration of natural compounds, with a specific focus on berberine. Berberine's potential as a treatment for urological cancers is investigated through an extensive examination of cellular and molecular mechanisms.
The comprehensive analysis reveals promising anticancer properties associated with berberine, substantiated by a wealth of experimental studies. The agent's impact on urological cancers is discussed, highlighting notable findings related to its efficacy and safety profile.
Given the high mortality rates and potential side effects associated with current standard treatments for urological cancers, the exploration of alternative, effective, and safer options is imperative. This review underscores berberine's therapeutic potential, shedding light on its anticancer effects and encouraging further research in the pursuit of enhanced treatment strategies.
泌尿系统癌症（包括前列腺癌、肾癌和膀胱癌）是全球性的健康挑战。目前的治疗方法包括化疗、放疗和手术，单独或联合使用，在疗效上存在局限性，且与明显的发病率和死亡率相关。
本综述探讨了其他治疗途径，强调了对天然化合物的探索，特别关注小檗碱。通过广泛研究细胞和分子机制，探讨了小檗碱作为治疗泌尿系统癌症的潜力。
全面分析揭示了小檗碱具有有前途的抗癌特性，这得到了大量实验研究的支持。讨论了该药物对泌尿系统癌症的影响，强调了与其疗效和安全性相关的显著发现。
鉴于目前泌尿系统癌症的标准治疗方法存在高死亡率和潜在的副作用，探索替代的、有效和更安全的选择是必要的。本综述强调了小檗碱的治疗潜力，揭示了其抗癌作用，并鼓励进一步研究以寻求增强的治疗策略。
