单侧急性中心性浆液性脉络膜视网膜病变患者的图形视网膜电图。

Pattern electroretinography in patients with unilateral acute central serous chorioretinopathy.

机构信息

Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

出版信息

Clin Exp Optom. 2020 Sep;103(5):656-662. doi: 10.1111/cxo.13016. Epub 2019 Dec 10.

DOI:10.1111/cxo.13016

PMID:31822040

Abstract

BACKGROUND

To evaluate the pattern electroretinography (PERG) in patients with acute central serous chorioretinopathy (CSCR) at baseline and after spontaneous resolution.

METHODS

A total of 32 patients (mean ± SD age: 38.8 ± 8.2 years, 71.9 per cent female) with unilateral acute CSCR and spontaneous resolution during follow-up period were included. The unaffected eyes of the study patients comprised the control group. The best-corrected visual acuity, PERG and optical coherence tomography findings were recorded both at baseline and following spontaneous resolution at two to four months.

RESULTS

The P50 and N95 amplitudes of the affected eyes were significantly lower than the control group both at baseline and after CSCR resolution (p < 0.001 for each). A significant increase was noted in both P50 and N95 amplitudes of the affected eyes from baseline to post-resolution (p < 0.001 for each). Subfoveal choroidal thickness was significantly higher in the affected eyes as compared with control eyes both at the baseline and after CSCR resolution along with a significant decrease in the affected eyes from baseline to post-resolution (p < 0.001 for each). The central retinal thickness was higher in the affected eyes as compared with the control eyes at baseline (p = 0.009), along with a significant decrease in the affected eyes from baseline to post-resolution (p < 0.001). Between the baseline P50 amplitude and the visual acuities of the affected eyes, a strong correlation was noted at baseline (r = -0.691, p < 0.001) and a moderate correlation was noted after CSCR resolution (r = -0.422, p = 0.031).

CONCLUSIONS

In conclusion, our findings revealed an association of CSCR with impaired P50 and N95 amplitudes and a significant improvement but not a complete recovery in both parameters after CSCR resolution. Our findings emphasise potential utility of PERG in the electrophysiological evaluation of functional impairment in CSCR patients and the likelihood of P50 amplitude to have a prognostic value in CSCR.

摘要

背景

评估急性中心性浆液性脉络膜视网膜病变（CSCR）患者基线时和自发缓解后的模式视网膜电图（PERG）。

方法

共纳入 32 例（平均年龄±标准差：38.8±8.2 岁，71.9%为女性）单侧急性 CSCR 患者，随访期间自发缓解。研究患者的未受影响的眼睛为对照组。在基线时和自发缓解后 2-4 个月记录最佳矫正视力、PERG 和光学相干断层扫描结果。

结果

受影响眼睛的 P50 和 N95 振幅在基线时和 CSCR 缓解后均明显低于对照组（p<0.001）。受影响眼睛的 P50 和 N95 振幅从基线到缓解后均显著增加（p<0.001）。与对照组相比，受影响眼睛的中心凹下脉络膜厚度在基线时和 CSCR 缓解后均显著升高，受影响眼睛的中心凹下脉络膜厚度从基线到缓解后显著降低（p<0.001）。受影响眼睛的中央视网膜厚度在基线时高于对照组（p=0.009），受影响眼睛的中央视网膜厚度从基线到缓解后显著降低（p<0.001）。在基线 P50 振幅和受影响眼睛的视力之间，在基线时观察到强烈的相关性（r=-0.691，p<0.001），在 CSCR 缓解后观察到中度相关性（r=-0.422，p=0.031）。