纤维素基聚合物乳化剂稳定的温敏和 pH 响应聚（N-乙烯基己内酰胺）水凝胶。
Cellulose-based polymeric emulsifier stabilized poly(N-vinylcaprolactam) hydrogel with temperature and pH responsiveness.
机构信息
Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Key Laboratory of Biomass Energy and Material, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, National Engineering Laboratory for Biomass Chemical Utilization, Nanjing 210042, Jiangsu Province, China; College of Chemical Engineering, Advanced Analysis and Testing Center, Nanjing Forestry University, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Nanjing 210037, Jiangsu Province, China.
Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Key Laboratory of Biomass Energy and Material, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, National Engineering Laboratory for Biomass Chemical Utilization, Nanjing 210042, Jiangsu Province, China.
出版信息
Int J Biol Macromol. 2020 Jan 15;143:190-199. doi: 10.1016/j.ijbiomac.2019.12.019. Epub 2019 Dec 9.
N-vinylcaprolactam (NVCL) is a temperature-responsive monomer, which is widely used for preparing responsive hydrogels. However, poor water solubility of NVCL necessitates the use of emulsifiers for better dispersion. Hydrolyzed epoxy soybean oil-grafted hydroxyethyl cellulose (H-ESO-HEC) polymeric emulsifier has excellent emulsifying properties, and the carboxyl groups afford pH-responsiveness to the hydrogels. A novel temperature- and pH-responsive cellulose-based hydrogel was prepared by combining NVCL and H-ESO-HEC. The hydrogel morphology, thermal stability, and swelling capacity were characterized, and it was also used as a dual-responsive drug preservative carrier. Scanning electron microscopy and thermogravimetric analysis confirmed the porous structure and good thermal stability, respectively, of the hydrogel. The hydrogel displayed a temperature- and pH-dependent swelling behavior and improved swelling capacity. The swelling behavior agreed well with the Korsmeyer-Peppas model and Schott's second-order kinetic model. The dual-responsive hydrogel has significant potential in the drug delivery systems owing to its biocompatibility and temperature and pH sensitivity.
N-乙烯基己内酰胺（NVCL）是一种温度响应性单体，广泛用于制备响应性水凝胶。然而，NVCL 的水溶性差，需要使用乳化剂以获得更好的分散性。水解环氧大豆油接枝羟乙基纤维素（H-ESO-HEC）聚合物乳化剂具有优异的乳化性能，并且羧基赋予水凝胶 pH 响应性。通过将 NVCL 和 H-ESO-HEC 结合，制备了一种新型的温度和 pH 双重响应的纤维素基水凝胶。对水凝胶的形态、热稳定性和溶胀性能进行了表征，并将其用作双重响应性药物载体。扫描电子显微镜和热重分析分别证实了水凝胶的多孔结构和良好的热稳定性。水凝胶表现出温度和 pH 依赖性溶胀行为和改善的溶胀能力。溶胀行为与 Korsmeyer-Peppas 模型和 Schott 二级动力学模型吻合较好。由于其生物相容性和温度及 pH 敏感性，双重响应水凝胶在药物传递系统中具有重要的应用潜力。
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