Li Yue, Xiong Feng, Xu Wen, Liu Side
Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Gastroenterol Res Pract. 2019 Nov 13;2019:5647161. doi: 10.1155/2019/5647161. eCollection 2019.
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases. In this prospective study, we aim to explore the role of angiotensin II (Ang II) and NLRP3 inflammasome in NAFLD patients.
We prospectively enrolled 96 patients in our hospital from September 2014 to February 2016. Patients were divided into two groups (NAFLD group and Control group), and the serum Ang II level, IL-1, IL-18, and lipids were analyzed. Correlation and multivariable analyses were used in order to identify the potential risk factors of NAFLD.
Although the two groups share a similar demographic background, the Ang II level of NAFLD group patients was significantly higher than that of the Control group (42.18 ± 12.37 vs. 36.69 ± 13.90, = 0.014) when abdominal ultrasound was used for grouping. This finding was confirmed when a FibroScan Cap value was selected to divide participants into the NAFLD group and Control group (41.16 ± 13.06 vs. 34.85 ± 12.64, = 0.040). Multivariable analysis showed that Ang II level is an independent risk factor of NAFLD whether abdominal ultrasound (OR = 1.056, = 0.037) or FibroScan Cap value (OR = 1.069, = 0.013) was deemed as the diagnostic standard. Furthermore, stepwise regression analysis was carried out between Ang II with other parameters and we discovered that Ang II had a linear correlation with IL-1.
Ang II levels of NAFLD patients significantly increased, and elevated Ang II level is an independent risk factor of NAFLD. Our preliminary results also indicate that Ang II may promote the development of NAFLD by activating NLRP3 inflammasome.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病之一。在这项前瞻性研究中，我们旨在探讨血管紧张素II（Ang II）和NLRP3炎性小体在NAFLD患者中的作用。
2014年9月至2016年2月，我们在我院前瞻性纳入了96例患者。将患者分为两组（NAFLD组和对照组），分析血清Ang II水平、白细胞介素-1（IL-1）、白细胞介素-18（IL-18）和血脂。采用相关性分析和多变量分析以确定NAFLD的潜在危险因素。
尽管两组患者的人口统计学背景相似，但在使用腹部超声进行分组时，NAFLD组患者的Ang II水平显著高于对照组（42.18±12.37对36.69±13.90，P = 0.014）。当选择FibroScan Cap值将参与者分为NAFLD组和对照组时，这一发现得到了证实（41.16±13.06对vs . 34.85±12.64，P = 0.04）。多变量分析表明，无论将腹部超声（比值比[OR]=1.056，P = 0.037）还是FibroScan Cap值（OR = 1.069，P = 0.013）视为诊断标准，Ang II水平都是NAFLD的独立危险因素。此外，对Ang II与其他参数进行逐步回归分析，我们发现Ang II与IL-1呈线性相关。
NAFLD患者的Ang II水平显著升高，且升高的Ang II水平是NAFLD的独立危险因素。我们的初步结果还表明，Ang II可能通过激活NLRP3炎性小体促进NAFLD的发展。
