越南南部城市移民中，乡村生活对螨虫致敏的保护作用消失了。

The protective effect of rural life on mite sensitization disappears among urban migrants in the South of Vietnam.

作者信息

Chu Ha Thi, Tran Thanh Ngoc, Doyen Virginie, Denis Olivier, Tran Thi Thu Thuy, Nguyen Thi Kieu Diem, Nguyen Huu Lan, Ngo Minh Xuan, Tran Thi Mong Hiep, Corazza Francis, Bouland Catherine, Hauglustaine Jean-Marie, Godin Isabelle, Michel Olivier

机构信息

Pham Ngoc Thach Hospital, Ho Chi Minh City, Viet Nam.

Clinic of Immuno-allergology, CHU Brugmann, Université Libre de Bruxelles (ULB), 4 Place A Van Gehuchten, B -1020, Brussels, Belgium.

出版信息

World Allergy Organ J. 2019 Nov 26;12(12):100085. doi: 10.1016/j.waojou.2019.100085. eCollection 2019 Dec.

DOI:10.1016/j.waojou.2019.100085

PMID:31827665

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6889047/

Abstract

BACKGROUND

Rapid urbanization combined with rural migration to urban areas in southern Vietnam could be risk factors for allergen sensitization, contributing to chronic respiratory diseases (CRD). We aimed to evaluate the prevalence of mite sensitization and its relation to house dust characteristics among rural and urban native and migrating populations with CRD.

METHODS

Rural (n = 19) and urban (n = 46) dwellings were defined on the basis of a home typology. Controls were western Belgian houses (n = 14). Besides the house characteristics, both endotoxin and mite allergens were measured in the settled dusts. The sensitization to mite allergens was defined by positive skin prick test (SPT) and concentration of specific IgE (sIgE)≥ 0.7 U/mL. The prevalence of mite sensitization was evaluated among 610 patients with CRD and compared according to both their home types and places of birth and residences.

RESULTS

The concentration of endotoxin (but not mite allergen) was higher in rural compared to urban dusts (440 (95%CI: 314-566) versus 170 (95%CI: 115-226) EU/mg; p < 0.0001). The prevalence of positive sIgE to Der p1 and Der p2 was significantly lower in rural (9% and 5%) compared to urban (15% and 9%) population, consistent with the positive SPT to mite (14% and 21%, respectively). Among the urban migrants, the risk of mite sensitization (SPT) was higher compared to the rural natives (OR: 1.79 (1.02-3.15), p < 0.05) and not different to the urban ones (OR: 1.35 (0.82-2.23) p NS).

CONCLUSION

In Vietnam, associated with higher endotoxin (but not allergen) dust concentrations, the risk of mite sensitization was lower in rural compared to the native urban population, but this protective effect could disappear among rural to urban migrants.

摘要

背景

越南南部快速的城市化进程以及农村人口向城市的迁移可能是变应原致敏的风险因素，进而导致慢性呼吸道疾病（CRD）。我们旨在评估慢性呼吸道疾病患者中，农村和城市本地及迁移人口的螨虫致敏率及其与室内灰尘特征的关系。

方法

根据房屋类型定义农村住宅（n = 19）和城市住宅（n = 46）。对照为比利时西部房屋（n = 14）。除房屋特征外，还对沉降灰尘中的内毒素和螨虫变应原进行了测量。螨虫变应原致敏定义为皮肤点刺试验（SPT）阳性且特异性IgE（sIgE）浓度≥0.7 U/mL。在610例慢性呼吸道疾病患者中评估螨虫致敏率，并根据其房屋类型、出生地和居住地进行比较。

结果

农村灰尘中的内毒素浓度（而非螨虫变应原）高于城市灰尘（440（95%CI：314 - 566）对170（95%CI：115 - 226）EU/mg；p < 0.0001）。农村人口中针对Der p1和Der p2的sIgE阳性率（分别为9%和5%）显著低于城市人口（分别为15%和9%），这与螨虫的皮肤点刺试验阳性结果一致（分别为14%和21%）。在城市移民中，螨虫致敏（皮肤点刺试验）的风险高于农村本地人（OR：1.79（1.02 - 3.15），p < 0.05），与城市本地人无差异（OR：1.35（0.82 - 2.23），p无统计学意义）。