Wen Si, Lv Weiwei, Ba Dan, Liu Jing, Cheng Guolin
College of Materials Science & Engineering , Huaqiao University , Xiamen 361021 , China . Email:
Chem Sci. 2019 Aug 12;10(39):9104-9108. doi: 10.1039/c9sc03245b. eCollection 2019 Oct 21.
The first successful example of deacylative annulation of 1,3-diones with sulfoxonium ylides was achieved through Ru(ii)-catalyzed C-C bond activation. The excellent chemoselectivity and broad substrate scope render this method a practical and versatile approach for the preparation of (hetero)aryl and alkenyl substituted furans, which are valuable units in many biologically active compounds and functional materials. A preliminary mechanistic study reveals that this process involves a deacylative α-ruthenation to generate key alkyl Ru(ii) intermediates with the release of a benzoic acid fragment.
通过钌（II）催化的C-C键活化实现了1,3 - 二酮与氧化锍叶立德的脱酰基环化反应的首个成功实例。出色的化学选择性和广泛的底物范围使该方法成为制备（杂）芳基和烯基取代呋喃的实用且通用的方法，这些呋喃是许多生物活性化合物和功能材料中有价值的单元。初步机理研究表明，该过程涉及脱酰基α-钌化反应，以生成关键的烷基钌（II）中间体并释放苯甲酸片段。
