Sivaguru Paramasivam, Wang Zikun, Zanoni Giuseppe, Bi Xihe
Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun 130024, China.
Chem Soc Rev. 2019 May 7;48(9):2615-2656. doi: 10.1039/c8cs00386f.
In recent years, radical C-C bond cleavage reactions have been increasingly understood and used to perform transformations that complement traditional ionic processes. However, to date radical C-C bond cleavage/functionalization reactions have not been the subject of a dedicated review. Herein we summarize the most recent and significant developments in the radical activation and functionalization of carbon-carbon bonds, with an emphasis on both synthetic outcomes and reaction mechanisms, and highlight how these radical C-C bond cleavage reactions enable challenging transformations.
近年来，人们对碳-碳键的自由基断裂反应有了越来越深入的理解，并将其用于实现补充传统离子过程的转化反应。然而，迄今为止，自由基碳-碳键断裂/官能化反应尚未成为专门综述的主题。在此，我们总结了碳-碳键自由基活化和官能化方面的最新重要进展，重点关注合成结果和反应机理，并强调这些自由基碳-碳键断裂反应如何实现具有挑战性的转化。
