关注西替利嗪在临床实践中的应用：30年后的重新评估
Focus on the cetirizine use in clinical practice: a reappraisal 30 years later.
作者信息
Corsico Angelo G, Leonardi Salvatore, Licari Amelia, Marseglia Gianluigi, Miraglia Del Giudice Michele, Peroni Diego G, Salpietro Carmelo, Ciprandi Giorgio
机构信息
1Division of Respiratory Diseases, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
2Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
出版信息
Multidiscip Respir Med. 2019 Dec 6;14:40. doi: 10.1186/s40248-019-0203-6. eCollection 2019.
Abstract
Antihistamines are currently one of the most commonly administered categories of drugs. They are used to treat symptoms that are secondary to histamine release, which is typical of certain allergic conditions, including rhinitis, conjunctivitis, asthma, urticaria, and anaphylaxis. Cetirizine belongs to the second-generation family, so, it is very selective for peripheral H1 receptors, is potent and quickly relieves symptoms, exerts additional anti-allergic/anti-inflammatory effects, and is usually well-tolerated. It has been marketed 30 years ago. In these years, a remarkable body of evidence has been built. The current review provides a practical update on the use of cetirizine in clinical practice.
摘要
抗组胺药是目前最常用的药物类别之一。它们用于治疗组胺释放继发的症状，这在某些过敏性疾病中很典型，包括鼻炎、结膜炎、哮喘、荨麻疹和过敏反应。西替利嗪属于第二代药物，因此，它对外周H1受体具有高度选择性，药效强且能迅速缓解症状，具有额外的抗过敏/抗炎作用，并且通常耐受性良好。它于30年前上市。这些年来，已经积累了大量显著的证据。本综述提供了西替利嗪在临床实践中应用的实用更新内容。
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Bioorg Chem. 2020 Jan;94:103351. doi: 10.1016/j.bioorg.2019.103351. Epub 2019 Oct 14.
2
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Arch Med Sci. 2019 Mar;15(2):537-553. doi: 10.5114/aoms.2017.68534. Epub 2018 Feb 4.
3
Safety of cetirizine ophthalmic solution 0.24% for the treatment of allergic conjunctivitis in adult and pediatric subjects.0.24%西替利嗪滴眼液治疗成人和儿童过敏性结膜炎的安全性。
Clin Ophthalmol. 2019 Feb 19;13:403-413. doi: 10.2147/OPTH.S186092. eCollection 2019.
4
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Clin Ophthalmol. 2018 Dec 13;12:2617-2628. doi: 10.2147/OPTH.S185835. eCollection 2018.
5
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7
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8
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Biomed Pharmacother. 2017 Sep;93:27-39. doi: 10.1016/j.biopha.2017.06.008. Epub 2017 Jun 13.
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Gastroenterol Rep (Oxf). 2018 Aug;6(3):228-230. doi: 10.1093/gastro/gow025. Epub 2016 Aug 29.
10
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