克里米亚共和国胎儿丙戊酸综合征病例系列
A Case Series of Fetal Valproate Syndrome in the Republic of Crimea.
作者信息
Rybalko Olga Nikolaevna, Kaladze Nikolai Nikolaevich, Sukhareva Irina Alexandrovna, Khoo Ching Soong
机构信息
Department of Pediatrics, Physiotherapy and Health Resorts, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Crimea, Russia.
Department of Public Health, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Crimea, Russia.
出版信息
J Neurosci Rural Pract. 2019 Oct;10(4):700-702. doi: 10.1055/s-0039-1700599. Epub 2019 Nov 6.
Valproic acid or valproate is a well-recognized potent teratogen. Antenatal exposure to this drug can cause fetal valproate syndrome (FVS), which is a constellation of distinctive dysmorphic features and congenital malformations. Despite an abundance of reports and registries about this syndrome, there is lack of information from Russia, in particular, the Republic of Crimea. We herein describe two cases of FVS from our registry.
丙戊酸或丙戊酸盐是一种公认的强效致畸剂。产前接触这种药物可导致胎儿丙戊酸盐综合征（FVS），这是一组独特的畸形特征和先天性畸形。尽管有大量关于该综合征的报告和登记，但来自俄罗斯，特别是克里米亚共和国的信息却很匮乏。我们在此描述了我们登记处的两例胎儿丙戊酸盐综合征病例。
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