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以严重高钙血症为首发表现的原发部位不明的神经内分泌癌：一例报告

Severe Hypercalcemia as the Initial Presentation of a Neuroendocrine Carcinoma of Unknown Primary Site: A Case Report.

作者信息

Shaka Hafeez, Raghavan Sairam

机构信息

Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, USA.

出版信息

Cureus. 2019 Nov 5;11(11):e6075. doi: 10.7759/cureus.6075.

DOI:10.7759/cureus.6075
PMID:31832292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6892572/
Abstract

Hypercalcemia is a common paraneoplastic syndrome that is associated with many malignancies. Hypercalcemia develops in malignancies through various mechanisms. Parathyroid hormone-related protein (PTHrP) is secreted by malignancy involving the lungs, breast, colorectum, bladder, and, rarely, neuroendocrine tumors. This is a rare case of severe hypercalcemia as the initial presentation of a high-grade metastatic neuroendocrine tumor of an unknown primary site.

摘要

高钙血症是一种常见的副肿瘤综合征，与多种恶性肿瘤相关。恶性肿瘤中高钙血症通过多种机制发生。甲状旁腺激素相关蛋白（PTHrP）由涉及肺、乳腺、结肠直肠、膀胱的恶性肿瘤分泌，神经内分泌肿瘤则很少见。这是一例罕见的严重高钙血症病例，为原发部位不明的高级别转移性神经内分泌肿瘤的首发表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/060b/6892572/5c34ded925ad/cureus-0011-00000006075-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/060b/6892572/d97f2771dc5e/cureus-0011-00000006075-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/060b/6892572/1a9c2da99d6b/cureus-0011-00000006075-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/060b/6892572/5c34ded925ad/cureus-0011-00000006075-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/060b/6892572/d97f2771dc5e/cureus-0011-00000006075-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/060b/6892572/1a9c2da99d6b/cureus-0011-00000006075-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/060b/6892572/5c34ded925ad/cureus-0011-00000006075-i03.jpg

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N Am J Med Sci. 2015 Nov;7(11):483-93. doi: 10.4103/1947-2714.170600.
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The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records.基层医疗中高钙血症患者的癌症风险：一项使用电子记录的队列研究。
Br J Cancer. 2014 Sep 23;111(7):1410-2. doi: 10.1038/bjc.2014.433. Epub 2014 Aug 5.
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[Case report; Small cell neuroendocrine carcinoma of the esophagus producing parathyroid hormone-related peptide with humoral hypercalcemia].[病例报告；食管小细胞神经内分泌癌伴甲状旁腺激素相关肽分泌及体液性高钙血症]
Nihon Naika Gakkai Zasshi. 2014 Mar 10;103(3):741-3. doi: 10.2169/naika.103.741.
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