Li Lei
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing 100730, China.
World J Clin Cases. 2019 Dec 6;7(23):4052-4056. doi: 10.12998/wjcc.v7.i23.4052.
Paraneoplastic neurological syndrome manifesting as secondary Parkinson disease caused by breast cancer is extremely rare.
We report a 39-year-old primipara of 31 gestational weeks, who presented with worsening tremors, facial stiffness and speech disfluencies, and decreased limb strength. Thorough physical examinations and auxiliary tests suggested secondary Parkinson's disease, but the pathogenesis was unknown. During the cesarean section at the 31 weeks plus 6 d, an exploration and liver biopsy revealed a metastatic, poorly differentiated adenocarcinoma. The positron emission tomography and immunohistochemical analysis confirmed a breast ductal carcinoma of stage IV. To our knowledge, only two reports have documented the association between the breast cancer and the Parkinson disease, and neither occurred in pregnant women.
Our case alerts the secondary Parkinson disease as the possible presentation of breast cancer, the most common malignancy during pregnancy.
由乳腺癌引起的表现为继发性帕金森病的副肿瘤性神经综合征极为罕见。
我们报告一名31孕周的39岁初产妇，她出现震颤加重、面部僵硬、言语不流畅以及肢体力量减弱。全面的体格检查和辅助检查提示继发性帕金森病，但发病机制不明。在31周加6天时行剖宫产，术中探查及肝脏活检发现转移性低分化腺癌。正电子发射断层扫描及免疫组化分析证实为IV期乳腺导管癌。据我们所知，仅有两篇报道记录了乳腺癌与帕金森病之间的关联，且均未发生在孕妇中。
我们的病例提示继发性帕金森病可能是孕期最常见的恶性肿瘤——乳腺癌的一种表现形式。
