Kakoulidis Ioannis, Skagias Lazaros, Politi Ekaterini
Breast Dis. 2015;35(3):157-66. doi: 10.3233/BD-150408.
Diagnosis of a clinical entity like pregnancy associated breast cancer (PABC) is as demanding and challenging as its rarity. Increasing incidence and controversy that exists in the literature upon prognosis, tumor aggressiveness and underlying mechanisms, highlight the importance of optimizing the diagnostic strategy in women with PABC. Adjustment of standard approach for breast cancer by modifying management methods and options plays key role in decision making. Knowledge of diagnostic modalities and their limitations, in accordance with awareness of physiologic hormone-induced changes of pregnancy and lactation, is the fundamental method of diagnosis in PABC. Thorough triple assessment (history/clinical examination, imaging and cytology/histology) enforces healthcare providers with all essential tools to avoid detrimental delay in diagnosis and to confront with their own hesitation to take action due to limited experience of the disease.
诊断像妊娠相关乳腺癌（PABC）这样的临床实体，既因罕见而极具挑战性，又对诊断要求极高。PABC发病率不断上升，且文献中在预后、肿瘤侵袭性及潜在机制方面存在争议，这凸显了优化PABC女性诊断策略的重要性。通过调整管理方法和选项来调整乳腺癌的标准方法在决策中起着关键作用。了解诊断方式及其局限性，并知晓妊娠和哺乳期生理激素引起的变化，是PABC诊断的基本方法。全面的三联评估（病史/临床检查、影像学及细胞学/组织学）为医疗服务提供者提供了所有必要工具，以避免诊断出现有害延误，并应对因对该疾病经验有限而导致的行动犹豫。
