Barrett R J, Harleman J H, Joseph E C
Smith Kline & French Research Ltd, Welwyn, Herts, UK.
J Appl Toxicol. 1988 Aug;8(4):233-8. doi: 10.1002/jat.2550080402.
The total LDH, HBDH and LDH isoenzyme activities were assessed in a number of rat tissues. HBDH did not correlate with LD1 and LD2 isoenzyme activity in tissues with high HBDH activity. HBDH therefore cannot be used as a marker for cardiac necrosis in the rat. In rats treated with isoprenaline and SK&F 94120 at doses producing myocardial necrosis, only the LD1 isoenzymes showed any significant change but only within the first 24 h of treatment. No statistically significant differences were seen in the plasma AST, CK, CK-MB and total LDH activities.
