Devi S A
Department of Zoology, Bangalore University.
Indian J Physiol Pharmacol. 1988 Jan-Mar;32(1):11-20.
Following a subcutaneous injection of isoproterenol (ISO) into adult rats (30 mg/100 g, B.W.), the cardiac total lactate dehydrogenase (LDH) activity was decreased by about 53.81% in less than 24 H. Restoration of myocardial LDH activity was seen at 24 H and 48 H. LDH-I activity exceeded LDH-V in the control heart, while LDH-I, LDH-II and LDH-III decreased at 48 H following ISO injection. These changes were associated with concomitant elevation in LDH-V activity. Percentage M-LDH was less than H-LDH till 12 H in the necrotic heart muscle but exceeded the latter at 24H and 48 H. Similar changes were marked in absolute H-LDH and M-LDH activities when compared with the total LDH activity. Histopathological studies revealed and confirmed the occurrence of infarcts. The results indicate the potential of myocardial tissue for efficient shifting of H-LDH synthesis to M-LDH synthesis in the necrotic heart.
给成年大鼠（体重30mg/100g）皮下注射异丙肾上腺素（ISO）后，心脏总乳酸脱氢酶（LDH）活性在24小时内降低了约53.81%。在24小时和48小时时观察到心肌LDH活性恢复。对照心脏中LDH-I活性超过LDH-V，而ISO注射后48小时，LDH-I、LDH-II和LDH-III降低。这些变化与LDH-V活性的同时升高有关。在坏死心肌中，直到12小时M-LDH百分比低于H-LDH，但在24小时和48小时时超过后者。与总LDH活性相比，绝对H-LDH和M-LDH活性也有类似变化。组织病理学研究揭示并证实了梗死的发生。结果表明坏死心脏中心肌组织有将H-LDH合成有效转变为M-LDH合成的潜力。
