Lacombe C, Bucherer C, Lelievre J C
Department of Biophysique, Pitié-Sapêtrière Hôpital, Paris, France.
Int Angiol. 1988 Apr-Jun;7(2 Suppl):21-4.
Rheological disorders, such as blood hyperviscosity, red blood cell (RBC) hyperaggregation or hypodeformability, may be responsible for vascular complications in diabetes. As pointed out by many reports, flavonoids are known to act on RBC rheology in relation with venous thrombosis. These disorders were evaluated by viscometry in order to follow the hemorheological impact of a flavonoid (Daflon 500 mg). Hemorheological effects of Daflon 500 mg, 6 tablets per day for 28 days, were tested in 18 diabetic patients by viscometric measurements carried out on 2 ml blood sample withdrawn on EDTA. Measurements, before and after treatment, were compared with usual statistical tests. The following results were obtained: (1) a decrease of blood viscosity, more pronounced at low shear rate; (2) a better RBC disaggregability process under shear. Therefore, the main conclusion was that the hemorheological improvement, observed after Daflon 500 mg treatment, due to a decrease of RBC aggregation, can induce a decrease of blood flow resistance and a reduction in stasis and resulting ischemia.
流变学紊乱，如血液高粘滞性、红细胞（RBC）过度聚集或变形性降低，可能是糖尿病血管并发症的原因。正如许多报告所指出的，黄酮类化合物已知与静脉血栓形成有关，可作用于红细胞流变学。通过粘度测定来评估这些紊乱情况，以跟踪一种黄酮类化合物（达弗隆500毫克）的血液流变学影响。对18名糖尿病患者进行了测试，让他们每天服用6片达弗隆500毫克，持续28天，通过对采集于乙二胺四乙酸（EDTA）抗凝的2毫升血样进行粘度测量来评估血液流变学效应。将治疗前后的测量结果与常规统计检验进行比较。得到了以下结果：（1）血液粘度降低，在低剪切速率下更为明显；（2）在剪切力作用下红细胞的解聚过程更好。因此，主要结论是，达弗隆500毫克治疗后观察到的血液流变学改善，是由于红细胞聚集减少，可导致血流阻力降低以及淤滞和由此产生的缺血情况减少。
