Amaechi Bennett T, AbdulAzees Parveez Ahamed, Alshareif Dina Ossama, Shehata Marina Adel, Lima Patrícia Paula de Carvalho Sampaio, Abdollahi Azadeh, Kalkhorani Parisa Samadi, Evans Veronica
Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900 USA.
BDJ Open. 2019 Dec 9;5:18. doi: 10.1038/s41405-019-0026-8. eCollection 2019.
This in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500 ppm fluoride in promoting remineralization and inhibiting caries development.
Two enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500 ppm F (amine fluoride) via intra-oral appliance worn by 30 adults in two-arm double blind randomized crossover study lasting 14 days per arm (ClinicalTrials.gov: NCT03681340). Baseline and post-test mineral loss and lesion depth (LD) were quantified using microradiography. One-sided -test of one group mean was used for intragroup comparison (baseline vs. post-test), while two-sided -test of two independent means was used to compare the two toothpaste groups.
Pairwise comparison (baseline vs. test) indicated significant ( < 0.0001) remineralization and LD reduction by either toothpaste; however, when compared against each other, there was no statistically significant difference in remineralization or LD reduction between the two toothpastes. No demineralization could be observed in sound enamel blocks exposed to either toothpaste. While F induced lesion surface lamination, HAP produced a more homogenous lesion remineralization.
10% hydroxyapatite achieved comparable efficacy with 500 ppm F in remineralizing initial caries and preventing demineralization. Thus the HAP toothpaste is confirmed to be equal to the fluoride toothpaste in this study.
本原位研究比较了两种含羟基磷灰石或500 ppm氟化物的牙膏在促进再矿化和抑制龋齿发展方面的效果。
在一项双臂双盲随机交叉研究中，30名成年人佩戴口腔矫治器，将两块釉质块（人乳牙），一块完好，一块有人工制造的龋损，分别暴露于含10%羟基磷灰石或500 ppm F（氟化胺）的牙膏中，每组持续14天（ClinicalTrials.gov：NCT03681340）。使用显微放射照相术对基线和测试后的矿物质流失及病变深度（LD）进行量化。组内比较（基线与测试后）采用一组均值的单侧检验，而比较两种牙膏组则采用两个独立均值的双侧检验。
成对比较（基线与测试）表明，两种牙膏均有显著的（P < 0.0001）再矿化和LD降低；然而，相互比较时，两种牙膏在再矿化或LD降低方面没有统计学上的显著差异。暴露于任何一种牙膏的完好釉质块中均未观察到脱矿。虽然氟导致病变表面分层，但羟基磷灰石使病变再矿化更均匀。
10%羟基磷灰石在使初始龋再矿化和预防脱矿方面与500 ppm氟化物具有相当的疗效。因此，在本研究中证实羟基磷灰石牙膏与含氟牙膏效果相当。
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