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三种再矿化剂对人工釉质病变再矿化效果的比较：一项体外研究。

Comparison of the remineralization effectiveness of three remineralizing agents on artificial enamel lesions: an in vitro study.

作者信息

Montaser Maha Mohamed, Youssef Heba, Mahmoud Ghada Mohamed

机构信息

The Arab Academy for Science, Technology and Maritime Transport- College of Dentistry-Alamein Campus, Alexandria, Egypt.

The pediatric Dentistry department at the Arab Academy for Science, Technology and Maritime Transport- College of Dentistry-Alamein Campus, Alexandria, Egypt.

出版信息

BDJ Open. 2025 May 5;11(1):44. doi: 10.1038/s41405-025-00330-y.

DOI:10.1038/s41405-025-00330-y
PMID:40324997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12053640/
Abstract

INTRODUCTION

Early enamel demineralization can be reversed through remineralization, which restores lost minerals to strengthen enamel and prevent decay.

AIM

This study evaluated the remineralization efficiency of three commercial treatments on artificially demineralized primary enamel.

METHODS

Forty exfoliated primary anterior teeth were demineralized and divided into five groups: untreated control, artificial saliva, fluoridated toothpaste, Curasept toothpaste, and BioMin toothpaste. The treatments were applied for 28 days. Remineralization efficacy was assessed using Vickers microhardness testing, surface roughness measurement, and Scanning electron microscope combined with EDX (SEM-EDX). One-way ANOVA and Tukey's HSD test were used for statistical analysis.

RESULTS

Microhardness and surface roughness tests confirmed BioMin's superior remineralization potential. Scanning electron microscopy showed that untreated enamel exhibited extensive demineralization, whereas treated groups displayed varying degrees of remineralization. BioMin demonstrated the highest calcium, phosphate, and fluoride incorporation, followed by Curasept and fluoridated toothpaste. The artificial saliva group showed no significant improvement over the control.

CONCLUSION

BioMin, followed by Curasept and fluoridated toothpaste, effectively remineralized demineralized enamel. BioMin's bioactive glass formulation provided the highest mineral gain, suggesting its potential for non-invasive enamel restoration in pediatric dentistry.

摘要

引言

早期牙釉质脱矿可通过再矿化逆转，再矿化可补充流失的矿物质以强化牙釉质并预防龋齿。

目的

本研究评估了三种市售治疗方法对人工脱矿的乳牙牙釉质的再矿化效率。

方法

将四十颗脱落的乳前牙脱矿并分为五组：未处理对照组、人工唾液、含氟牙膏、Curasept牙膏和BioMin牙膏。这些治疗方法应用28天。使用维氏显微硬度测试、表面粗糙度测量以及扫描电子显微镜结合能谱仪（SEM-EDX）评估再矿化效果。采用单因素方差分析和Tukey's HSD检验进行统计分析。

结果

显微硬度和表面粗糙度测试证实了BioMin具有卓越的再矿化潜力。扫描电子显微镜显示，未处理的牙釉质呈现广泛脱矿，而处理组则表现出不同程度的再矿化。BioMin显示出最高的钙、磷和氟掺入量，其次是Curasept和含氟牙膏。人工唾液组与对照组相比无显著改善。

结论

BioMin其次是Curasept和含氟牙膏能有效使脱矿牙釉质再矿化。BioMin的生物活性玻璃配方提供了最高的矿物质增加量，表明其在儿童牙科无创牙釉质修复方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/b1392487e866/41405_2025_330_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/b8c2d1ae3589/41405_2025_330_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/3656828cb6e7/41405_2025_330_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/ff3fe5d3c098/41405_2025_330_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/9fa337e4af7f/41405_2025_330_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/5790b0f39a7c/41405_2025_330_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/b1392487e866/41405_2025_330_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/b8c2d1ae3589/41405_2025_330_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/03e1f52afe37/41405_2025_330_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/863e688b547d/41405_2025_330_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/2c6f8b9803bb/41405_2025_330_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/3656828cb6e7/41405_2025_330_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/ff3fe5d3c098/41405_2025_330_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/9fa337e4af7f/41405_2025_330_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/5790b0f39a7c/41405_2025_330_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7354/12053640/b1392487e866/41405_2025_330_Fig9_HTML.jpg

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