Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi Key Lab of Sugarcane Biology, College of Agriculture, Guangxi University, Nanning 530004, China.
Cells. 2019 Dec 12;8(12):1621. doi: 10.3390/cells8121621.
The nucleosome is the structural and fundamental unit of eukaryotic chromatin. The chromatin remodeling complexes change nucleosome composition, packaging and positioning to regulate DNA accessibility for cellular machinery. SWI2/SNF2-Related 1 Chromatin Remodeling Complex (SWR1-C) belongs to the INO80 chromatin remodeling family and mainly catalyzes the exchange of H2A-H2B with the H2A.Z-H2B dimer. The replacement of H2A.Z into nucleosomes affects nucleosome stability and chromatin structure. Incorporation of H2A.Z into the chromatin and its physiochemical properties play a key role in transcriptional regulation during developmental and environmental responses. In , various studies have uncovered several pivotal roles of SWR1-C. Recently, notable progress has been achieved in understanding the role of SWR1-C in plant developmental and physiological processes such as DNA damage repair, stress tolerance, and flowering time. The present article introduces the SWR1-C and comprehensively reviews recent discoveries made in understanding the function of the SWR1 complex in plants.
核小体是真核染色质的结构和基本单位。染色质重塑复合物改变核小体的组成、包装和定位，以调节细胞机器对 DNA 的可及性。SWI2/SNF2 相关 1 染色质重塑复合物（SWR1-C）属于 INO80 染色质重塑家族，主要催化 H2A-H2B 与 H2A.Z-H2B 二聚体的交换。H2A.Z 进入核小体取代 H2A 会影响核小体的稳定性和染色质结构。H2A.Z 掺入染色质及其理化性质在发育和环境响应过程中的转录调控中起着关键作用。在[1]中，多项研究揭示了 SWR1-C 的几个关键作用。最近，在理解 SWR1-C 在植物发育和生理过程中的作用方面取得了显著进展，如 DNA 损伤修复、应激耐受和开花时间。本文介绍了 SWR1-C，并全面回顾了理解 SWR1 复合物在植物中的功能的最新发现。
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