Farag H F, Salem A, el-Hifni S A, Kandil M
Department of Parasitology, University of Alexandria, Egypt.
J Trop Med Hyg. 1988 Oct;91(5):240-4.
The present study is an evaluation of bithionol treatment in established fascioliasis. Eight patients were enrolled in the study. All were passing eggs of Fasciola spp. and seven had concomitant Schistosoma mansoni infection. The clinical and haematological findings conformed with the known picture of fascioliasis. Bitin tablets (200 mg) were administered in the dose of 30 mg kg-1 body wt every other day for five doses. Eggs were counted during and for 4 months after the end of therapy. Fasciola ova disappeared after the second or third dose giving a cure rate of 100%. Ova of S. mansoni did not show any change in number. As regards the liver function tests; bilirubin, SGOT and SGPT values were within the normal range and were not affected by treatment. A raised SAP level was observed before therapy which was significantly higher after bithionol. Creatinine phosphokinase and lactate dehydrogenase enzymes and kidney function tests showed almost normal values and were not altered by therapy. It was concluded that Bitin was a potent fasciolicidal drug in the dose used. No side effects were observed.
本研究是对已确诊的片形吸虫病患者使用硫双二氯酚进行治疗的评估。8名患者参与了该研究。所有患者均排出片形吸虫属虫卵，其中7名同时感染曼氏血吸虫。临床和血液学检查结果与已知的片形吸虫病情况相符。给予比特诺尔片（200毫克），剂量为每千克体重30毫克，隔日服用一次，共服用5次。在治疗期间及治疗结束后4个月内对虫卵进行计数。在服用第二或第三次剂量后，片形吸虫卵消失，治愈率达100%。曼氏血吸虫卵数量未出现任何变化。关于肝功能检查，胆红素、谷草转氨酶和谷丙转氨酶值均在正常范围内，且不受治疗影响。治疗前观察到碱性磷酸酶水平升高，使用硫双二氯酚治疗后显著更高。肌酸磷酸激酶和乳酸脱氢酶以及肾功能检查显示几乎为正常值，且未因治疗而改变。得出的结论是，在所使用的剂量下，比特诺尔是一种有效的杀片形吸虫药物。未观察到副作用。
