Department of Paediatrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, Lundlaan 6, 3584, EA, Utrecht, the Netherlands; Center of Translational Immunology, University Medical Centre Utrecht, Utrecht, Lundlaan 6, 3584, EA, Utrecht, the Netherlands.
Center of Translational Immunology, University Medical Centre Utrecht, Utrecht, Lundlaan 6, 3584, EA, Utrecht, the Netherlands.
Clin Immunol. 2020 Feb;211:108324. doi: 10.1016/j.clim.2019.108324. Epub 2019 Dec 13.
During severe respiratory syncytial virus (RSV) bronchiolitis there is a massive influx of activated neutrophils to the lungs. An exaggerated immune response contributes to lung damage and disease severity during RSV infection. We have previously shown that normal adult neutrophil function can be modulated by agonists of SIRL-1. Here we aimed to measure the potential of two immune checkpoints: SIRL-1 and LAIR-1, to regulate the function of fresh blood and sputum neutrophils from infants with and without severe RSV bronchiolitis. We show a modest inhibition of the oxidative burst through SIRL-1 and LAIR-1, in control and RSV-infected infants. In addition, SIRL-1 and LAIR-1 inhibited neutrophil extracellular traps (NET) formation by sputum neutrophils of RSV patients. Altogether our data show that inhibitory receptors LAIR-1 and SIRL-1 can be used to regulate neutrophil function.
在严重呼吸道合胞病毒（RSV）细支气管炎中，大量活化的中性粒细胞涌入肺部。过度的免疫反应导致 RSV 感染期间肺损伤和疾病严重程度增加。我们之前已经表明，正常成人中性粒细胞功能可以通过 SIRL-1 的激动剂来调节。在这里，我们旨在测量两个免疫检查点：SIRL-1 和 LAIR-1，以调节患有和不患有严重 RSV 细支气管炎的婴儿的新鲜血液和痰液中性粒细胞的功能。我们显示 SIRL-1 和 LAIR-1 通过控制和 RSV 感染的婴儿适度抑制氧化爆发。此外，SIRL-1 和 LAIR-1 抑制 RSV 患者痰液中性粒细胞的细胞外陷阱（NET）形成。总的来说，我们的数据表明抑制性受体 LAIR-1 和 SIRL-1 可用于调节中性粒细胞功能。
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