Koops Maaike, Meyaard Linde
Center of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.
Eur J Immunol. 2025 Feb;55(2):e202451465. doi: 10.1002/eji.202451465.
Innate immune cells express a plethora of inhibitory receptors, many of which recognize molecular patterns. An appropriate balance between signaling via activating and inhibitory pattern recognition receptors is important for a proper immune response while preventing immunopathology. V-set and transmembrane domain containing 1 (VSTM1), also known as signal inhibitory receptor on leukocytes-1 (SIRL-1), is an inhibitory receptor expressed on myeloid cells. VSTM1 can modulate the function of myeloid cells, by inhibiting reactive oxygen species and neutrophil extracellular trap formation. VSTM1 recognizes shared molecular patterns both from endogenous and microbial origin, defining it as an inhibitory pattern recognition receptor. VSTM1 is involved in various pathological conditions, including autoimmune disorders and cancer, and its restricted expression on myeloid cells highlights its potential as a specific therapeutic target. This review summarizes the characteristics and function of VSTM1 in health and disease.
固有免疫细胞表达大量抑制性受体，其中许多识别分子模式。通过激活型和抑制型模式识别受体进行的信号传导之间的适当平衡对于适当的免疫反应很重要，同时可预防免疫病理。含V结构域和跨膜结构域1（VSTM1），也称为白细胞信号抑制受体1（SIRL-1），是一种在髓系细胞上表达的抑制性受体。VSTM1可通过抑制活性氧和中性粒细胞胞外陷阱形成来调节髓系细胞的功能。VSTM1识别内源性和微生物来源的共同分子模式，将其定义为抑制性模式识别受体。VSTM1参与多种病理状况，包括自身免疫性疾病和癌症，其在髓系细胞上的限制性表达突出了其作为特定治疗靶点的潜力。本综述总结了VSTM1在健康和疾病中的特征及功能。
