Shi Lei, Hager Tobias, Fries Fabian Norbert, Daas Loay, Holbach Leonard, Hofmann-Rummelt Carmen, Zemova Elena, Seitz Berthold, Szentmáry Nóra
Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar 66424, Germany.
Department of Ophthalmology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, P.R. China.
Int J Ophthalmol. 2019 Dec 18;12(12):1966-1971. doi: 10.18240/ijo.2019.12.20. eCollection 2019.
We analysed histologically two keratitis (AK) eyes with anterior and posterior segment inflammation and blindness. Two enucleated eyes of 2 patients (age 45 and 51y) with AK (PCR of epithelial abrasion positive) were analysed. Histological analysis was performed using hematoxylin-eosin, periodic acid-Schiff and Gömöri-methenamine silver staining. We could not observe trophozoites or cysts neither in the cornea nor in other ocular tissues. Meanwhile, we found uveitis, retinal vasculitis and scleritis in these eyes, due to the long-standing, recalcitrant AK. So in this stage of AK, systemic immune suppression may be necessary for a longer time period.
我们对两只患有眼前段和后段炎症及失明的阿米巴角膜炎（AK）眼睛进行了组织学分析。对两名患有AK（上皮擦伤PCR检测呈阳性）的患者（年龄分别为45岁和51岁）的两只摘除眼球进行了分析。使用苏木精-伊红、过碘酸-希夫和Gömöri-亚甲胺银染色进行组织学分析。我们在角膜或其他眼组织中均未观察到滋养体或包囊。同时，由于长期顽固的AK，我们在这些眼睛中发现了葡萄膜炎、视网膜血管炎和巩膜炎。因此，在AK的这个阶段，可能需要较长时间进行全身免疫抑制。
