镉对欧洲比目鱼（Pleuronectes flesus L.）血液学以及血液和造血组织中δ-氨基乙酰丙酸脱水酶（ALA-D）活性的影响
The effect of cadmium on the hematology and on the activity of delta-aminolevulinic acid dehydratase (ALA-D) in blood and hematopoietic tissues of the flounder, Pleuronectes flesus L.
作者信息
Johansson-Sjöbeck M L, Larsson A
机构信息
Department of Zoophysiology, University of Göteborg, Sweden.
出版信息
Environ Res. 1978 Oct;17(2):191-204. doi: 10.1016/0013-9351(78)90021-x.
Flounders (Pleuronectes flesus) were exposed to sublethal levels of cadmium (5, 50, and 500 micrograms of Cd2+/liter) for periods of 4 and 9 weeks, and the hematological response as well as the effect on the activity of delta-aminolevulinic acid dehydratase (ALA-D) in blood and blood-forming tissues were investigated. Significant reductions of hematocrit, hemoglobin, and red blood cell count were found in the cadmium-exposed fish. This anemic response was apparent even in flounders exposed to the lowest cadmium concentration, approximately corresponding to 1/4000 of the 96-hr LC50 value. The anemia was accompanied by a significant increase of the ALA-D activity in renal tissues. This indicates a compensatory stimulation of the introductory steps of the hemoglobin biosynthesis. However, the formation of hemoglobin does not seem to be accomplished, which might be due to a disturbed iron metabolism. The cadmium exposure also resulted in a significant increase of the number of lymphocytes, indicating an action on the immunological defense of the fish.
将比目鱼（欧洲比目鱼）暴露于亚致死水平的镉（5、50和500微克Cd2+/升）中4周和9周，研究其血液学反应以及对血液和造血组织中δ-氨基乙酰丙酸脱水酶（ALA-D）活性的影响。在暴露于镉的比目鱼中发现血细胞比容、血红蛋白和红细胞计数显著降低。即使在暴露于最低镉浓度（约相当于96小时半数致死浓度值的1/4000）的比目鱼中，这种贫血反应也很明显。贫血伴随着肾组织中ALA-D活性的显著增加。这表明对血红蛋白生物合成起始步骤有代偿性刺激。然而，血红蛋白的形成似乎并未完成，这可能是由于铁代谢紊乱所致。镉暴露还导致淋巴细胞数量显著增加，表明对鱼的免疫防御有作用。
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