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无机铅对虹鳟(Salmo gairdnerii)δ-氨基乙酰丙酸脱水酶活性及血液学指标的影响

Effects of inorganic lead on delta-aminolevulinic acid dehydratase activity and hematological variables in the rainbow trout, Salmo gairdnerii.

作者信息

Johansson-Sjöbeck M L, Larsson A

出版信息

Arch Environ Contam Toxicol. 1979;8(4):419-31. doi: 10.1007/BF01056348.

DOI:10.1007/BF01056348
PMID:485210
Abstract

The activity of the enzyme delta-aminolevulinic acid dehydratase (ALA-D) was strongly depressed in erythrocytes, spleen and renal tissue of rainbow trouts (Salmo gairdnerii) exposed to sublethal levels of inorganic lead (10, 75 and 300 microgram Pb2+/L) for 30 days. The fish exposed to the highest lead concentration also showed an anemic response and basophilic stippling of erythrocytes. The lead exposure did not cause any alteration of the white blood cell picture. The ALA-D inhibition, the anemia and basophilic stippling seemed to persist in the lead-exposed fish even after a recovery period of seven weeks in lead-free water.

摘要

将虹鳟鱼(Salmo gairdnerii)暴露于亚致死水平的无机铅(10、75和300微克Pb2+/升)30天,其红细胞、脾脏和肾脏组织中的δ-氨基乙酰丙酸脱水酶(ALA-D)活性受到强烈抑制。暴露于最高铅浓度的鱼还出现贫血反应和红细胞嗜碱性点彩。铅暴露未引起白细胞图像的任何改变。即使在无铅水中恢复七周后,铅暴露鱼中的ALA-D抑制、贫血和嗜碱性点彩似乎仍然存在。

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