Karpova V N
Med Radiol (Mosk). 1988 Oct;33(10):46-9.
The author described an experiment on 34 dogs aged 2 to 4, of both sexes, with the body mass of 14.8-0.6 kg. 8 animals entered into the age control group, the rest of the animals were exposed to single combined irradiation (9 dogs), to isolated gamma-irradiation at a dose of 25.8 mC/kg (7 dogs) and submicron 239Pu oxide irradiation at doses less than 7 kBq/kg (10 dogs). Methods of electrocardiography and tetrapolar chest rheography were also used. The results of the experiment have demonstrated that 239Pu inhalation causes hemodynamic shifts (a decrease in stroke, cardiac and rheographic indices). External gamma-irradiation at the above dose produces no significant effect on hemodynamic indices. Combined exposure to external and internal irradiation contributes to earlier formation of hemodynamic shifts as compared to radionuclide action. Combined and isolated effects of external and internal irradiation result in cardiac rhythm destabilization manifested in increased development of sinus arrhythmia and enhancement of its degree as compared to those in the control group.
作者描述了一项针对34只年龄在2至4岁、雌雄皆有、体重为14.8 - 0.6千克的狗的实验。8只动物进入年龄对照组，其余动物分别接受单次联合照射（9只狗）、剂量为25.8毫库仑/千克的单独γ射线照射（7只狗）以及剂量小于7千贝克勒尔/千克的亚微米239Pu氧化物照射（10只狗）。实验还采用了心电图和四极胸壁血流图检查方法。实验结果表明，吸入239Pu会导致血液动力学改变（每搏输出量、心输出量和血流图指数降低）。上述剂量的外部γ射线照射对血液动力学指标无显著影响。与放射性核素作用相比，外部和内部照射的联合暴露会促使血液动力学改变更早形成。外部和内部照射的联合及单独作用会导致心律不稳定，表现为窦性心律失常的发生率增加以及与对照组相比其程度加重。
