初级运动皮层的活动与视觉反馈有关。

Activity in Primary Motor Cortex Related to Visual Feedback.

机构信息

Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA 15213, USA.

Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA 15213, USA; Systems Neuroscience Center, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

出版信息

Cell Rep. 2019 Dec 17;29(12):3872-3884.e4. doi: 10.1016/j.celrep.2019.11.069.

DOI:10.1016/j.celrep.2019.11.069

PMID:31851920

Abstract

Neural modulation in primate motor cortex exhibits complex patterns. We found that modulation during reaching could be separated into discrete temporal epochs. To determine if these epochs are driven by behavioral events, monkeys performed variations of a center-out reaching task. Monkeys viewed a computer cursor matched to hand position and a radial target at 1 of 16 locations. In some trials, they performed a visuomotor rotation (the cursor moved at an angle to the hand). After adaptation, encoding changes for single units are temporally structured: adaptation could affect one temporal component of a unit's response but not another. In half the normal and perturbed trials, we removed visual feedback before movement. Adaptation-sensitive firing components toward the end of movement are often weak or absent during reaches without feedback. These results show that temporal structure in motor cortical activity is driven by behavior, with a discrete component related to visual feedback.

摘要

灵长类运动皮层的神经调节表现出复杂的模式。我们发现，在进行伸手动作时，调节可以分为离散的时间区间。为了确定这些区间是否由行为事件驱动，猴子进行了一系列中心向外伸手任务的变化。猴子看到一个与手位置匹配的计算机光标和一个位于 16 个位置之一的径向目标。在一些试验中，它们进行了视觉运动旋转（光标以相对于手的角度移动）。适应后，单个单元的编码变化在时间上是有结构的：适应可以影响单元响应的一个时间成分，但不能影响另一个。在一半的正常和受干扰的试验中，我们在运动前去除了视觉反馈。在没有反馈的伸手运动中，接近运动终点的适应敏感的放电成分通常较弱或不存在。这些结果表明，运动皮层活动中的时间结构是由行为驱动的，其中一个离散的成分与视觉反馈有关。