Zhang Wenjia, Qin Zhongqiao, Xian Kecong, Tang Shuhong
Department of Neurosurgery, Guigang People's Hospital, Guigang City, Guangxi Zhuang Autonomous Region, China.
J Int Med Res. 2020 Mar;48(3):300060519882202. doi: 10.1177/0300060519882202. Epub 2019 Dec 18.
To investigate the effect of plasma homocysteine (Hcy) and C-reactive protein (CRP) levels in patients with craniocerebral injury.
A retrospective analysis of data from patients with craniocerebral injury who underwent surgery. Patients were stratified according to the extent of the craniocerebral injury into severe, moderate and mild craniocerebral injury groups. Serum Hcy and CRP levels were determined at admission, at 7 days after treatment and at 3 months after injury. Univariate and multivariate Cox regression analyses were undertaken to identify prognostic factors.
The study enrolled 96 patients: 29 patients with mild injury; 33 patients with moderate injury; and 34 patients with severe injury. Serum Hcy and CRP levels at admission were significantly higher in the severe craniocerebral injury group than in the other two groups; and they were significantly higher the moderate craniocerebral injury group compared with the mild craniocerebral injury group. Serum Hcy and CRP levels of the three groups of patients were significantly lower after 7 days of treatment than those before treatment. The levels of Hcy and CRP were positively correlated in all three groups.
Serum Hcy and CRP levels in patients could be used to monitor the condition and prognosis of patients with craniocerebral injury.
探讨血浆同型半胱氨酸（Hcy）和C反应蛋白（CRP）水平在颅脑损伤患者中的作用。
对接受手术治疗的颅脑损伤患者的数据进行回顾性分析。根据颅脑损伤程度将患者分为重度、中度和轻度颅脑损伤组。于入院时、治疗7天后及伤后3个月测定血清Hcy和CRP水平。采用单因素和多因素Cox回归分析确定预后因素。
本研究共纳入96例患者，其中轻度损伤29例，中度损伤33例，重度损伤34例。重度颅脑损伤组入院时血清Hcy和CRP水平显著高于其他两组；中度颅脑损伤组血清Hcy和CRP水平显著高于轻度颅脑损伤组。三组患者治疗7天后血清Hcy和CRP水平均显著低于治疗前。三组患者Hcy和CRP水平均呈正相关。
患者血清Hcy和CRP水平可用于监测颅脑损伤患者的病情及预后。
