Department of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China (mainland).
Department of Thoracic and Cardiac Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China (mainland).
Med Sci Monit. 2019 Dec 19;25:9721-9727. doi: 10.12659/MSM.918888.
BACKGROUND The aim of this study was to analyze the diagnostic value of thin bronchoscopy lung biopsy for peripheral pulmonary lesions under non-real-time guidance of radial ultrasound (RP-EBUS). MATERIAL AND METHODS We used a retrospective analysis of ultrasound images of 165 patients with peripheral pulmonary disease admitted to Suzhou Municipal Hospital Affiliated to Nanjing Medical University from February 2016 to December 2018 who were given RP-EBUS examination. Ultrasound images were obtained for all patients. There were 76 patients treated using traditional positioning method as the control group; 89 patients were treated by probe combined with bronchoscopy positioning method as the research group where the biopsy of the lesion along the path of the ultrasound probe was taken. The positive rate of the 2 methods was observed, and the factors affecting the quality of ultra-thin bronchoscopy under RP-EBUS non-real-time guidance were analyzed. RESULTS The detection rate of the study group was 77.64%, which was significantly higher than that in control group, which was 63.16% (χ²=5.238, P<0.05). The number of biopsies in the study group was 6±1.25, which was significantly lower than that of the control group which was 9±1.87 (t=4.116, P<0.05). The diagnostic positive rate of the RP-EBUS probe was significantly higher than that of the RP-EBUS probe (χ²=5.081, P<0.05). CONCLUSIONS The diagnostic positive rate of RP-EBUS non-real-time guided subtotal bronchoscopy lung biopsy for peripheral lung disease using probe combined with bronchoscopy positioning method was higher than the traditional positioning method, and the number of biopsies in the study group was significantly lower than that in the control group, which was related to the size, location, whether the probe was wrapped, or the characteristics of the ultrasound image.
本研究旨在分析径向超声（RP-EBUS）实时引导下经支气管镜肺活检对周围性肺部病变的诊断价值。
回顾性分析 2016 年 2 月至 2018 年 12 月南京医科大学附属苏州医院收治的 165 例经 RP-EBUS 检查的周围性肺部疾病患者的超声图像，所有患者均行超声图像检查。其中 76 例行传统定位法治疗患者为对照组，89 例行探头联合支气管镜定位法治疗患者为观察组，沿超声探头路径对病变行活检。观察两种方法的阳性率，分析影响 RP-EBUS 非实时引导下超微支气管镜质量的因素。
观察组的检出率为 77.64%，明显高于对照组的 63.16%（χ²=5.238，P<0.05）。观察组活检次数为 6±1.25 次，明显低于对照组的 9±1.87 次（t=4.116，P<0.05）。RP-EBUS 探头诊断阳性率明显高于 RP-EBUS 探头（χ²=5.081，P<0.05）。
探头联合支气管镜定位法行 RP-EBUS 非实时引导下经支气管镜肺活检对周围性肺部疾病的诊断阳性率高于传统定位法，且观察组活检次数明显少于对照组，这与病灶大小、位置、探头是否包裹、超声图像特征有关。
