Department of Experimental and Health Sciences, CIBERNED, ICREA, University Pompeu Fabra (UPF), Barcelona, Spain.
Spanish National Cardiovascular Research Center, Madrid, Spain.
FEBS J. 2020 Feb;287(3):406-416. doi: 10.1111/febs.15182. Epub 2020 Jan 3.
Aging is characterized by the progressive dysfunction of most tissues and organs, which has been linked to the regenerative decline of their resident stem cells over time. Skeletal muscle provides a stark example of this decline. Its stem cells, also called satellite cells, sustain muscle regeneration throughout life, but at advanced age they fail for largely undefined reasons. Here, we discuss current understanding of the molecular processes regulating satellite cell maintenance throughout life and how age-related failure of these processes contributes to muscle aging. We also highlight the emerging field of rejuvenating biology to restore features of youthfulness in satellite cells, with the ultimate goal of slowing down or reversing the age-related decline in muscle regeneration.
衰老是大多数组织和器官功能逐渐失调的特征，这与它们驻留的干细胞随时间推移而再生能力下降有关。骨骼肌就是这种衰退的一个明显例子。其干细胞，也称为卫星细胞，终生维持肌肉再生，但在老年时，由于尚未明确的原因而衰竭。在这里，我们讨论了目前对调节卫星细胞维持的分子过程的理解，以及这些过程随年龄相关的失败如何导致肌肉衰老。我们还强调了新兴的恢复生物学领域，以恢复卫星细胞的年轻特征，最终目标是减缓或逆转与年龄相关的肌肉再生下降。
