Chung Seung Yeun, Lee Chang Geol
Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
Head Neck. 2020 May;42(5):854-859. doi: 10.1002/hed.26052. Epub 2019 Dec 19.
Generally, radiotherapy for patients with early glottic cancer includes treatment of the whole larynx. This study was conducted to evaluate the treatment outcomes and toxicity in patients who received single vocal cord irradiation (SVCI) for T1a classification glottic cancer.
A total of 34 patients diagnosed with clinical T1aN0M0 classification squamous cell carcinoma of the glottis who received radiotherapy to the single vocal cord were included for analysis.
Median follow-up period was 41.3 months (range, 6.4-124.5 months). The 3-year and 5-year local control (LC) rates were both 96.8%. Grade 3 radiation dermatitis was observed as severe acute toxicity in two (6%) patients. No patients experienced any severe late toxicity events during follow-up.
SVCI showed good LC, low acute and late toxicities, and reasonable voice recovery. SVCI may be considered a feasible treatment strategy for patients with T1a glottic cancer.
一般来说，早期声门癌患者的放射治疗包括对整个喉部进行治疗。本研究旨在评估接受T1a期声门癌单声带照射（SVCI）患者的治疗效果和毒性。
共纳入34例诊断为临床T1aN0M0期声门鳞状细胞癌且接受单声带放射治疗的患者进行分析。
中位随访期为41.3个月（范围6.4 - 124.5个月）。3年和5年局部控制（LC）率均为96.8%。两名（6%）患者出现3级放射性皮炎作为严重急性毒性反应。随访期间无患者发生任何严重晚期毒性事件。
SVCI显示出良好的局部控制、低急性和晚期毒性以及合理的声音恢复。SVCI可被认为是T1a期声门癌患者的一种可行治疗策略。
