早期声门癌的超分割放疗：来自单一中心的真实世界数据。
Ultra-Hypofractionated Radiotherapy for Early-Stage Glottic Cancer: Real-World Data From a Single Center.
作者信息
Gundog Mete, Kiraz Esin
机构信息
Department of Radiation Oncology, Erciyes University, Kayseri, Turkey.
出版信息
Head Neck. 2025 Sep;47(9):2383-2391. doi: 10.1002/hed.28139. Epub 2025 Apr 1.
BACKGROUND
In recent years, smaller-volume radiotherapy has attracted attention. It appears to be a safe and effective treatment for glottic laryngeal cancer. This study evaluated the results of ultra-hypofractionated radiotherapy for early glottic laryngeal cancer in unfit patients.
METHODS
This retrospective study analyzed 22 patients diagnosed with early glottic cancer between June 2017 and January 2021. The involved vocal cord was treated with 35-42.5 Gy in 5 fractions.
RESULTS
On a 59-month median follow-up, the 5-year overall survival and local control rate were 68.2% and 94.7%, respectively. However, the 5-year larynx preservation rate was 89.7%. Chondronecrosis was observed in one patient (4.5%), and soft tissue necrosis in one patient (4.5%). PTV (> 41.08 Gy) was found to be statistically significant in surgery-needed events (HR: 22.4, 95% CI: 1.9-252.1, p = 0.01).
CONCLUSION
Single-cord ultra-hypofractionated radiotherapy appears to be an effective treatment for local control. However, the risk of radionecrosis is higher at doses above 41.08 Gy.
背景
近年来，小剂量放疗受到关注。它似乎是声门型喉癌的一种安全有效的治疗方法。本研究评估了超分割放疗对不适合手术的早期声门型喉癌患者的治疗效果。
方法
这项回顾性研究分析了2017年6月至2021年1月期间诊断为早期声门型癌的22例患者。受累声带接受5次分割，剂量为35 - 42.5 Gy。
结果
中位随访59个月时，5年总生存率和局部控制率分别为68.2%和94.7%。然而，5年喉保留率为89.7%。1例患者（4.5%）出现软骨坏死，1例患者（4.5%）出现软组织坏死。在需要手术的事件中，PTV（> 41.08 Gy）具有统计学意义（HR：22.4，95% CI：1.9 - 252.1，p = 0.01）。
结论
单声带超分割放疗似乎是一种有效的局部控制治疗方法。然而，剂量高于41.08 Gy时放射性坏死的风险更高。
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