Ishida T
Second Department of Surgery, Tokyo Medical and Dental University, Japan.
Nihon Geka Gakkai Zasshi. 1988 Jun;89(6):898-905.
The present study was performed to determine the effects of PGE1 on the liver circulations. Adult mongrel dogs were used for this experimental study. Following the continuous infusion of PGE1 to the hepatic artery (HA) and portal vein (PV), the change of hepatic arterial flow (HAF) and portal venous flow (PVF) was measured by the electromagnetic flow meter, and hepatic tissue flow (HTF) by the hydrogen clearance meter. Hepatic enzymes were also measured at the same time. A single infusion of saline was done for the control. HAF and HTF increased significantly by the continuous infusion of over 0.5ng/Kg/min of PGE1 to HA. PVF and HTF also showed an increase by the continuous infusion of 100ng/Kg/min of PGE1 to PV. Compared with the control group, lactate acid and pyruvate acid levels remained low in the PGE1 infused group. The optimum dose of PGE1 to HA was thought to be 1.0-2.0ng/Kg/min. The results of experimental studies suggest that the direct infusion of PGE1 to the liver may prevent the ischemic change of hepatic metabolism during and after the surgical interventions.
本研究旨在确定前列腺素E1（PGE1）对肝脏循环的影响。本实验研究使用成年杂种犬。在向肝动脉（HA）和门静脉（PV）持续输注PGE1后，用电磁流量计测量肝动脉血流量（HAF）和门静脉血流量（PVF）的变化，用氢清除仪测量肝组织血流量（HTF）。同时还测量了肝酶。对照组进行单次生理盐水输注。向HA持续输注超过0.5ng/（kg·min）的PGE1可使HAF和HTF显著增加。向PV持续输注100ng/（kg·min）的PGE1也可使PVF和HTF增加。与对照组相比，PGE1输注组的乳酸和丙酮酸水平保持较低。认为向HA输注PGE1的最佳剂量为1.0 - 2.0ng/（kg·min）。实验研究结果表明，向肝脏直接输注PGE1可能预防手术干预期间及之后肝脏代谢的缺血性变化。
