Kawachi S, Shimazu M, Wakabayashi G, Tanabe M, Shirasugi N, Kumamoto Y, Karahashi T, Yoshida M, Kitajima M
Department of Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Transplantation. 1997 Jul 27;64(2):205-9. doi: 10.1097/00007890-199707270-00004.
Prostaglandin E1 (PGE1) has been reported to have a protective effect in experimental and clinical models of liver damage. The aim of this study was to elucidate the effects of the intraportal infusion of PGE1 on hepatic blood flow and graft viability after orthotopic liver transplantation in pigs.
First, the hepatic arterial flow (HAF), portal venous flow (PVF), and liver tissue blood flow (LTBF) were measured during the continuous intravenous or intraportal infusion of PGE1. Second, two groups of pigs underwent orthotopic liver transplantation: group A, untreated controls; and group B, animals that received intraportal PGE1 for 2 hr after vascular reconstruction of the allograft. Changes in HAF, PVF, LTBF, and hepatic function were measured.
The intraportal infusion of PGE1 significantly increased HAF and had no effect on blood pressure, PVF, or LTBF. In group B, HAF and LTBF increased significantly with time. In group A, HAF remained unchanged and a decrease in LTBF was observed. Group B exhibited a higher arterial ketone body ratio and a greater bile flow compared with group A. A significant elevation in serum glutamic oxaloacetic transaminase concentration was observed in group A, but not in group B.
This study demonstrates that the intraportal infusion of PGE1 improves hepatic allograft blood flow, predominantly through an effect on HAF, and may improve graft viability after orthotopic liver transplantation.
据报道，前列腺素E1（PGE1）在肝损伤的实验和临床模型中具有保护作用。本研究的目的是阐明门静脉内输注PGE1对猪原位肝移植后肝血流和移植物活力的影响。
首先，在持续静脉内或门静脉内输注PGE1期间，测量肝动脉血流（HAF）、门静脉血流（PVF）和肝组织血流（LTBF）。其次，两组猪接受原位肝移植：A组为未治疗的对照组；B组为在同种异体移植物血管重建后接受门静脉内PGE1输注2小时的动物。测量HAF、PVF、LTBF和肝功能的变化。
门静脉内输注PGE1显著增加HAF，对血压、PVF或LTBF无影响。在B组中，HAF和LTBF随时间显著增加。在A组中，HAF保持不变，观察到LTBF下降。与A组相比，B组表现出更高的动脉酮体比率和更大的胆汁流量。在A组中观察到血清谷氨酸草酰乙酸转氨酶浓度显著升高，而在B组中未观察到。
本研究表明，门静脉内输注PGE1可改善肝同种异体移植物血流，主要通过对HAF的影响，并且可能改善原位肝移植后的移植物活力。
