铜催化的乙烯基芳烃与掩蔽烷基亲电试剂的烷基芳基化反应。
Cu-Catalyzed Alkylarylation of Vinylarenes with Masked Alkyl Electrophiles.
机构信息
State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis , Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences , 155 Yangqiao Road West , Fuzhou , Fujian 350002 , PR China.
University of Chinese Academy of Sciences , Beijing 100049 , PR China.
出版信息
Org Lett. 2020 Jan 17;22(2):620-625. doi: 10.1021/acs.orglett.9b04392. Epub 2019 Dec 19.
A Cu-catalyzed synthesis of a range of value-added 1,1-diarylalkanes by radical alkylarylation of vinylarenes with alkyl peroxides as masked alkyl electrophiles is reported. The reaction features broad substrate scope, good functional group tolerance, and mild reaction conditions. Various bioactive molecules and key pharmaceutical intermediates have been easily synthesized by this method, demonstrating its synthetic value.
报道了一种通过自由基烷基芳基化反应，以 Cu 为催化剂，将烷基过氧化物作为掩蔽烷基亲电试剂，合成一系列有价值的 1,1-二芳基烷烃的方法。该反应具有广泛的底物范围、良好的官能团耐受性和温和的反应条件。通过这种方法可以很容易地合成各种生物活性分子和关键的药物中间体，显示了其合成价值。
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